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Table 3 The concentrations of amino acids and their metabolites in control and model groups

From: Establishment of the circadian metabolic phenotype strategy in spontaneously hypertensive rats: a dynamic metabolomics study

NoNameAbbreviationFormulaConcentration/ng/20 µL
ZT0ZT4ZT8
ControlModelControlModelControlModel
1O-phospho-l-serineP-SerC3H8NO6P7.53 ± 1.288.77 ± 0.569.18 ± 1.0210.54 ± 0.8*6.99 ± 0.727.82 ± 0.75
2TaurineTauC2H7NO3S89.4 ± 14.87156.16 ± 29.23**105.62 ± 12.52185.32 ± 53.88*63.45 ± 12.86118.08 ± 10.4**
3UreaUreaCH4N2O1993.58 ± 280.63181.64 ± 501.01**2270.86 ± 249.242875.2 ± 296.76**1443.99 ± 181.692733.1 ± 669.73**
4Aspartic acidAspC4H7NO42.83 ± 0.976.48 ± 6.844.74 ± 1.0315.07 ± 8.03**3.76 ± 1.178.39 ± 0.59**
5l-ThreonineThrC4H9NO3109.36 ± 26.32148.87 ± 2.96**121.97 ± 25.43155.03 ± 8.01*71.35 ± 10.6116.6 ± 8.37**
6SerineSerC3H7NO395.47 ± 23.79144.88 ± 16.41**123.28 ± 24.26170.17 ± 5.26**74.35 ± 9.42140.79 ± 24.99**
7GlycineGlyC2H5NO291.39 ± 25.25138.56 ± 27.34*108.99 ± 14.9140.77 ± 9.84**66.44 ± 7.16132.32 ± 13.29**
8beta-AlanineAlaC3H7NO2121.32 ± 23.3174.18 ± 27.67**187.86 ± 38.23234.73 ± 15.76*125.61 ± 23.49157.25 ± 19.44*
9l(+)-CitrullineCitC6H13N3O350.63 ± 9.9947.95 ± 7.5757.64 ± 10.2271.43 ± 9.61*36.84 ± 7.0345.7 ± 5.67*
10ValineValC5H11NO279.59 ± 13.24140.78 ± 12.19**104.48 ± 14.53139.69 ± 12.85**61.31 ± 7.34106.94 ± 7.88**
11CystathionineCysC7H14N2O4S38.01 ± 11.1250.41 ± 15.5635.16 ± 8.6547.93 ± 8.13*31.54 ± 4.0446.81 ± 7.8**
12l-MethionineMetC5H11NO2S31.49 ± 6.3647.75 ± 3.05*39 ± 5.8451.01 ± 2.63**23.03 ± 2.6840.86 ± 3.06**
13IsoleucineIleC6H13NO236.31 ± 6.469.89 ± 9.12**51.01 ± 8.365.38 ± 5.87*28.68 ± 3.7949.32 ± 3.52**
14LeucineLeuC6H13NO266.86 ± 13.04123.81 ± 8.72**96.98 ± 14.18126.69 ± 10.73**52.23 ± 7.0597.77 ± 8.24**
15TyrosineTyrC9H11NO348.99 ± 10.4586.63 ± 7.77**61.85 ± 8.0193.72 ± 8.26**30.17 ± 6.3659.57 ± 2.58**
16PhenylalaninePheC9H11NO240.07 ± 10.7155.39 ± 4.23*54.47 ± 7.8754.33 ± 3.1632.52 ± 2.6645.65 ± 2.73**
17EthanolamineEOHNH2C2H7NO31.14 ± 6.2537.51 ± 2.2536 ± 4.937.75 ± 1.7319.6 ± 3.630.29 ± 3.43**
18AmmoniaNH3NH321.31 ± 4.2220.96 ± 1.2831.9 ± 2.2522.71 ± 1.07**14.58 ± 2.720.99 ± 6.01*
19l-OrnithineOrnC5H12N2O225.2 ± 7.3155.59 ± 26.4849.03 ± 16.4969.61 ± 24.3126.53 ± 7.9346.35 ± 13.06*
20l-LysineLysC6H14N2O2177.08 ± 49.69242.23 ± 34.89*302.61 ± 69.01312.84 ± 21.66175.9 ± 25.65224.72 ± 18.64**
21l-HistidineHisC6H9N3O239.06 ± 11.1573.36 ± 5.81**58.14 ± 12.3892.04 ± 5.41**33.11 ± 3.2469.15 ± 9.37**
22ArginineArgC6H14N4O287.69 ± 29.44130.39 ± 34.45143.46 ± 47.1228.83 ± 45.41*83.09 ± 22.36159.51 ± 18.75**
234-Hydroxy-l-prolineHyproC5H9NO317.3 ± 4.8621.81 ± 3.5123.53 ± 4.7531.29 ± 1.5*28.78 ± 4.7526.8 ± 2.1
24ProlineProC5H9NO2123.73 ± 24134.37 ± 35.81142.67 ± 31.36179.19 ± 13.8*135.99 ± 29.41120.27 ± 22.2
NoNameAbbreviationFormulaConcentration/ng/20 µL
ZT12ZT16ZT20
ControlModelControlModelControlModel
1O-phospho-l-serineP-SerC3H8NO6P6.09 ± 0.47.57 ± 0.29**7.49 ± 0.99.06 ± 0.76*7.7 ± 1.337.68 ± 0.51
2TaurineTauC2H7NO3S52.71 ± 7.595.58 ± 29.03*75.61 ± 19.82191.56 ± 56.4**88.45 ± 37.02136.85 ± 22.83*
3UreaUreaCH4N2O1643.64 ± 257.532518.04 ± 2332507.3 ± 462.323523.42 ± 675.16*2393.68 ± 230.252892.78 ± 216.13*
4Aspartic acidAspC4H7NO42.37 ± 0.864.04 ± 43.51 ± 0.745.99 ± 5.023.72 ± 1.489.11 ± 2.46*
5l-ThreonineThrC4H9NO368.13 ± 8.72134.55 ± 15.87**133.06 ± 23.01193.15 ± 32.08**133.96 ± 26.15144.05 ± 15.28
6SerineSerC3H7NO368.98 ± 9.34136.75 ± 17.07**117.15 ± 23.54172.09 ± 18.44**108.03 ± 10.88130.9 ± 6.82**
7GlycineGlyC2H5NO266.05 ± 8.43127.28 ± 25.53**114.36 ± 17.37146.73 ± 12.3**106.06 ± 14.38125.89 ± 6.29*
8beta-AlanineAlaC3H7NO293.75 ± 20.84131.79 ± 10.98**143.49 ± 30.66189.73 ± 41.22151.78 ± 58.34152.69 ± 17
9l(+)-CitrullineCitC6H13N3O340.17 ± 7.2955.04 ± 11.06**68.99 ± 11.2471.19 ± 9.4169.23 ± 14.8152.05 ± 8.39*
10ValineValC5H11NO252.87 ± 5.59106.9 ± 3.65**89.59 ± 15.55151.47 ± 7.11**91.22 ± 18.03123.81 ± 18.32*
11CystathionineCysC7H14N2O4S34.76 ± 4.311.07 ± 1.72**50.9 ± 16.5457.42 ± 12.8134.06 ± 16.7745.99 ± 9.01
12l-MethionineMetC5H11NO2S22.91 ± 2.7340.5 ± 2.83**38.06 ± 8.2256.63 ± 6.95**38.56 ± 8.6242.59 ± 2.62
13IsoleucineIleC6H13NO222.89 ± 3.2948.25 ± 2.12**40.26 ± 9.2773.56 ± 3.86**38.95 ± 8.659.34 ± 11.08**
14LeucineLeuC6H13NO241.1 ± 691.79 ± 3.38**75.7 ± 15.17135.66 ± 7.29**74.04 ± 17.26109.66 ± 18.72**
15TyrosineTyrC9H11NO325.66 ± 3.9846.96 ± 9.19**41.95 ± 7.7267.78 ± 6.33**51.25 ± 22.2668.33 ± 12.43
16PhenylalaninePheC9H11NO231.4 ± 2.4348.76 ± 2.51**50.56 ± 7.665.59 ± 6.27**50.68 ± 14.2551.38 ± 4.87
17EthanolamineEOHNH2C2H7NO19.3 ± 4.7337.32 ± 3.23**34.33 ± 3.7643.61 ± 9.4237.24 ± 9.2637.71 ± 2.92
18AmmoniaNH3NH319.28 ± 13.3421.92 ± 0.928.19 ± 1.5727.45 ± 2.4328.29 ± 1.4823.15 ± 1.32**
19l-OrnithineOrnC5H12N2O223.43 ± 5.0942.01 ± 6.8**37.49 ± 13.0259.26 ± 10.63*35.61 ± 11.2949.12 ± 14.99
20l-LysineLysC6H14N2O2155.67 ± 22.76179.67 ± 21.54221.42 ± 29.33243.95 ± 14.51221.59 ± 63.78180.88 ± 9.13
21l-HistidineHisC6H9N3O231.39 ± 2.3464.71 ± 2.26**54.53 ± 9.4387.35 ± 9.32**55.3 ± 13.8366.53 ± 6.2
22ArginineArgC6H14N4O274.32 ± 16.8130.84 ± 12.62**86.02 ± 15.09151.18 ± 23.29**90.94 ± 39.81117.64 ± 9.45
234-Hydroxy-l-prolineHyproC5H9NO330.73 ± 4.2621.38 ± 6.01*26.25 ± 6.1924.48 ± 4.1523.97 ± 4.2318.92 ± 2.65*
24ProlineProC5H9NO2132.18 ± 19.35139.03 ± 19.59175.92 ± 43.29190.65 ± 44.34175.39 ± 43.84118.41 ± 22.13*
  1. ** p < 0.01 model group compared with control group
  2. p < 0.05 model group compared with control group