No | Name | Abbreviation | Formula | Concentration/ng/20 µL | |||||
---|---|---|---|---|---|---|---|---|---|
ZT0 | ZT4 | ZT8 | |||||||
Control | Model | Control | Model | Control | Model | ||||
1 | O-phospho-l-serine | P-Ser | C3H8NO6P | 7.53 ± 1.28 | 8.77 ± 0.56 | 9.18 ± 1.02 | 10.54 ± 0.8* | 6.99 ± 0.72 | 7.82 ± 0.75 |
2 | Taurine | Tau | C2H7NO3S | 89.4 ± 14.87 | 156.16 ± 29.23** | 105.62 ± 12.52 | 185.32 ± 53.88* | 63.45 ± 12.86 | 118.08 ± 10.4** |
3 | Urea | Urea | CH4N2O | 1993.58 ± 280.6 | 3181.64 ± 501.01** | 2270.86 ± 249.24 | 2875.2 ± 296.76** | 1443.99 ± 181.69 | 2733.1 ± 669.73** |
4 | Aspartic acid | Asp | C4H7NO4 | 2.83 ± 0.97 | 6.48 ± 6.84 | 4.74 ± 1.03 | 15.07 ± 8.03** | 3.76 ± 1.17 | 8.39 ± 0.59** |
5 | l-Threonine | Thr | C4H9NO3 | 109.36 ± 26.32 | 148.87 ± 2.96** | 121.97 ± 25.43 | 155.03 ± 8.01* | 71.35 ± 10.6 | 116.6 ± 8.37** |
6 | Serine | Ser | C3H7NO3 | 95.47 ± 23.79 | 144.88 ± 16.41** | 123.28 ± 24.26 | 170.17 ± 5.26** | 74.35 ± 9.42 | 140.79 ± 24.99** |
7 | Glycine | Gly | C2H5NO2 | 91.39 ± 25.25 | 138.56 ± 27.34* | 108.99 ± 14.9 | 140.77 ± 9.84** | 66.44 ± 7.16 | 132.32 ± 13.29** |
8 | beta-Alanine | Ala | C3H7NO2 | 121.32 ± 23.3 | 174.18 ± 27.67** | 187.86 ± 38.23 | 234.73 ± 15.76* | 125.61 ± 23.49 | 157.25 ± 19.44* |
9 | l(+)-Citrulline | Cit | C6H13N3O3 | 50.63 ± 9.99 | 47.95 ± 7.57 | 57.64 ± 10.22 | 71.43 ± 9.61* | 36.84 ± 7.03 | 45.7 ± 5.67* |
10 | Valine | Val | C5H11NO2 | 79.59 ± 13.24 | 140.78 ± 12.19** | 104.48 ± 14.53 | 139.69 ± 12.85** | 61.31 ± 7.34 | 106.94 ± 7.88** |
11 | Cystathionine | Cys | C7H14N2O4S | 38.01 ± 11.12 | 50.41 ± 15.56 | 35.16 ± 8.65 | 47.93 ± 8.13* | 31.54 ± 4.04 | 46.81 ± 7.8** |
12 | l-Methionine | Met | C5H11NO2S | 31.49 ± 6.36 | 47.75 ± 3.05* | 39 ± 5.84 | 51.01 ± 2.63** | 23.03 ± 2.68 | 40.86 ± 3.06** |
13 | Isoleucine | Ile | C6H13NO2 | 36.31 ± 6.4 | 69.89 ± 9.12** | 51.01 ± 8.3 | 65.38 ± 5.87* | 28.68 ± 3.79 | 49.32 ± 3.52** |
14 | Leucine | Leu | C6H13NO2 | 66.86 ± 13.04 | 123.81 ± 8.72** | 96.98 ± 14.18 | 126.69 ± 10.73** | 52.23 ± 7.05 | 97.77 ± 8.24** |
15 | Tyrosine | Tyr | C9H11NO3 | 48.99 ± 10.45 | 86.63 ± 7.77** | 61.85 ± 8.01 | 93.72 ± 8.26** | 30.17 ± 6.36 | 59.57 ± 2.58** |
16 | Phenylalanine | Phe | C9H11NO2 | 40.07 ± 10.71 | 55.39 ± 4.23* | 54.47 ± 7.87 | 54.33 ± 3.16 | 32.52 ± 2.66 | 45.65 ± 2.73** |
17 | Ethanolamine | EOHNH2 | C2H7NO | 31.14 ± 6.25 | 37.51 ± 2.25 | 36 ± 4.9 | 37.75 ± 1.73 | 19.6 ± 3.6 | 30.29 ± 3.43** |
18 | Ammonia | NH3 | NH3 | 21.31 ± 4.22 | 20.96 ± 1.28 | 31.9 ± 2.25 | 22.71 ± 1.07** | 14.58 ± 2.7 | 20.99 ± 6.01* |
19 | l-Ornithine | Orn | C5H12N2O2 | 25.2 ± 7.31 | 55.59 ± 26.48 | 49.03 ± 16.49 | 69.61 ± 24.31 | 26.53 ± 7.93 | 46.35 ± 13.06* |
20 | l-Lysine | Lys | C6H14N2O2 | 177.08 ± 49.69 | 242.23 ± 34.89* | 302.61 ± 69.01 | 312.84 ± 21.66 | 175.9 ± 25.65 | 224.72 ± 18.64** |
21 | l-Histidine | His | C6H9N3O2 | 39.06 ± 11.15 | 73.36 ± 5.81** | 58.14 ± 12.38 | 92.04 ± 5.41** | 33.11 ± 3.24 | 69.15 ± 9.37** |
22 | Arginine | Arg | C6H14N4O2 | 87.69 ± 29.44 | 130.39 ± 34.45 | 143.46 ± 47.1 | 228.83 ± 45.41* | 83.09 ± 22.36 | 159.51 ± 18.75** |
23 | 4-Hydroxy-l-proline | Hypro | C5H9NO3 | 17.3 ± 4.86 | 21.81 ± 3.51 | 23.53 ± 4.75 | 31.29 ± 1.5* | 28.78 ± 4.75 | 26.8 ± 2.1 |
24 | Proline | Pro | C5H9NO2 | 123.73 ± 24 | 134.37 ± 35.81 | 142.67 ± 31.36 | 179.19 ± 13.8* | 135.99 ± 29.41 | 120.27 ± 22.2 |
No | Name | Abbreviation | Formula | Concentration/ng/20 µL | |||||
---|---|---|---|---|---|---|---|---|---|
ZT12 | ZT16 | ZT20 | |||||||
Control | Model | Control | Model | Control | Model | ||||
1 | O-phospho-l-serine | P-Ser | C3H8NO6P | 6.09 ± 0.4 | 7.57 ± 0.29** | 7.49 ± 0.9 | 9.06 ± 0.76* | 7.7 ± 1.33 | 7.68 ± 0.51 |
2 | Taurine | Tau | C2H7NO3S | 52.71 ± 7.5 | 95.58 ± 29.03* | 75.61 ± 19.82 | 191.56 ± 56.4** | 88.45 ± 37.02 | 136.85 ± 22.83* |
3 | Urea | Urea | CH4N2O | 1643.64 ± 257.53 | 2518.04 ± 233 | 2507.3 ± 462.32 | 3523.42 ± 675.16* | 2393.68 ± 230.25 | 2892.78 ± 216.13* |
4 | Aspartic acid | Asp | C4H7NO4 | 2.37 ± 0.86 | 4.04 ± 4 | 3.51 ± 0.74 | 5.99 ± 5.02 | 3.72 ± 1.48 | 9.11 ± 2.46* |
5 | l-Threonine | Thr | C4H9NO3 | 68.13 ± 8.72 | 134.55 ± 15.87** | 133.06 ± 23.01 | 193.15 ± 32.08** | 133.96 ± 26.15 | 144.05 ± 15.28 |
6 | Serine | Ser | C3H7NO3 | 68.98 ± 9.34 | 136.75 ± 17.07** | 117.15 ± 23.54 | 172.09 ± 18.44** | 108.03 ± 10.88 | 130.9 ± 6.82** |
7 | Glycine | Gly | C2H5NO2 | 66.05 ± 8.43 | 127.28 ± 25.53** | 114.36 ± 17.37 | 146.73 ± 12.3** | 106.06 ± 14.38 | 125.89 ± 6.29* |
8 | beta-Alanine | Ala | C3H7NO2 | 93.75 ± 20.84 | 131.79 ± 10.98** | 143.49 ± 30.66 | 189.73 ± 41.22 | 151.78 ± 58.34 | 152.69 ± 17 |
9 | l(+)-Citrulline | Cit | C6H13N3O3 | 40.17 ± 7.29 | 55.04 ± 11.06** | 68.99 ± 11.24 | 71.19 ± 9.41 | 69.23 ± 14.81 | 52.05 ± 8.39* |
10 | Valine | Val | C5H11NO2 | 52.87 ± 5.59 | 106.9 ± 3.65** | 89.59 ± 15.55 | 151.47 ± 7.11** | 91.22 ± 18.03 | 123.81 ± 18.32* |
11 | Cystathionine | Cys | C7H14N2O4S | 34.76 ± 4.3 | 11.07 ± 1.72** | 50.9 ± 16.54 | 57.42 ± 12.81 | 34.06 ± 16.77 | 45.99 ± 9.01 |
12 | l-Methionine | Met | C5H11NO2S | 22.91 ± 2.73 | 40.5 ± 2.83** | 38.06 ± 8.22 | 56.63 ± 6.95** | 38.56 ± 8.62 | 42.59 ± 2.62 |
13 | Isoleucine | Ile | C6H13NO2 | 22.89 ± 3.29 | 48.25 ± 2.12** | 40.26 ± 9.27 | 73.56 ± 3.86** | 38.95 ± 8.6 | 59.34 ± 11.08** |
14 | Leucine | Leu | C6H13NO2 | 41.1 ± 6 | 91.79 ± 3.38** | 75.7 ± 15.17 | 135.66 ± 7.29** | 74.04 ± 17.26 | 109.66 ± 18.72** |
15 | Tyrosine | Tyr | C9H11NO3 | 25.66 ± 3.98 | 46.96 ± 9.19** | 41.95 ± 7.72 | 67.78 ± 6.33** | 51.25 ± 22.26 | 68.33 ± 12.43 |
16 | Phenylalanine | Phe | C9H11NO2 | 31.4 ± 2.43 | 48.76 ± 2.51** | 50.56 ± 7.6 | 65.59 ± 6.27** | 50.68 ± 14.25 | 51.38 ± 4.87 |
17 | Ethanolamine | EOHNH2 | C2H7NO | 19.3 ± 4.73 | 37.32 ± 3.23** | 34.33 ± 3.76 | 43.61 ± 9.42 | 37.24 ± 9.26 | 37.71 ± 2.92 |
18 | Ammonia | NH3 | NH3 | 19.28 ± 13.34 | 21.92 ± 0.9 | 28.19 ± 1.57 | 27.45 ± 2.43 | 28.29 ± 1.48 | 23.15 ± 1.32** |
19 | l-Ornithine | Orn | C5H12N2O2 | 23.43 ± 5.09 | 42.01 ± 6.8** | 37.49 ± 13.02 | 59.26 ± 10.63* | 35.61 ± 11.29 | 49.12 ± 14.99 |
20 | l-Lysine | Lys | C6H14N2O2 | 155.67 ± 22.76 | 179.67 ± 21.54 | 221.42 ± 29.33 | 243.95 ± 14.51 | 221.59 ± 63.78 | 180.88 ± 9.13 |
21 | l-Histidine | His | C6H9N3O2 | 31.39 ± 2.34 | 64.71 ± 2.26** | 54.53 ± 9.43 | 87.35 ± 9.32** | 55.3 ± 13.83 | 66.53 ± 6.2 |
22 | Arginine | Arg | C6H14N4O2 | 74.32 ± 16.8 | 130.84 ± 12.62** | 86.02 ± 15.09 | 151.18 ± 23.29** | 90.94 ± 39.81 | 117.64 ± 9.45 |
23 | 4-Hydroxy-l-proline | Hypro | C5H9NO3 | 30.73 ± 4.26 | 21.38 ± 6.01* | 26.25 ± 6.19 | 24.48 ± 4.15 | 23.97 ± 4.23 | 18.92 ± 2.65* |
24 | Proline | Pro | C5H9NO2 | 132.18 ± 19.35 | 139.03 ± 19.59 | 175.92 ± 43.29 | 190.65 ± 44.34 | 175.39 ± 43.84 | 118.41 ± 22.13* |