Fig. 3

Transcriptional expression of CD79, MS4A1, CTLA4 and CD3D in the mesenteric adipose tissue (MAT) of Crohn’s disease (CD) patients. a mRNA levels (qRT-PCR) of CD79, MS4A1, CTLA4 and CD3D were investigated in the MAT of CD patients (CD group) compared to controls (CTR group). All these genes were differentially expressed in the MAT of CD compared to the control, identified by RNA sequencing. b Transcriptional levels of pro-inflammatory markers in the MAT and ileal mucosa of CD patients (CD group) and respective controls (CTR group). For CD, n = 26; for CTR (MAT), n=17, for CTR (ileum), n = 12, ∗p < 0.05 is considered statistically significant versus control group. c Network analysis was performed by Ingenuity Pathway Analysis (IPA) of the differentially expressed genes by RNA sequencing. The networks represent the molecular relationships between genes and genes products that are present in CD-MAT and that belong to B cell or T cell pathways