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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Bevacizumab treatment of meningeal melanoma metastases

Fig. 5

Changes in the expression of angiogenesis-related genes after bevacizumab treatment. The expression of 84 angiogenesis-related genes in bevacizumab-treated versus that in untreated meningeal A-07 and D-12 tumors. The lines indicate a twofold difference in expression level. Of the 84 genes, 17 (20%) showed a significant and more than twofold higher expression in bevacizumab-treated than in untreated A-07 tumors (red symbols), whereas none of the 84 genes showed expression levels that were significantly different in bevacizumab-treated and untreated D-12 tumors. Gene expression was measured with quantitative PCR and normalized to the expression of 5 housekeeping genes. Points: mean of 3 tumors. Bars: standard error

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