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Table 2 Comparison of clinical and laboratory parameters of participants according to CART rs2239670 genotypes

From: Cocaine and amphetamine-regulated transcript prepropeptide gene (CARTPT) polymorphism interacts with Diet Quality Index-International (DQI-I) and Healthy Eating Index (HEI) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals

  Women (n = 140) Men (n = 147)
GG (n = 90) AG (n = 28) AA (n = 22) P* GG (n = 109) AG (n = 30) AA (n = 8) P*
LDL-C (mg/dL) 116.66 (34.00) 124.32 (37.89) 122.82 (28.47) 0.645 122.07 (29.43) 114.48 (24.87) 125.68 (27.63) 0.563
HDL (mg/dL) 46.40 (9.37) 50.05 (7.87) 47.50 (10.25) 0.347 43.00 (6.89) 39.22 (6.87) 43.00 (6.74) 0.122
Cholesterol (mg/dL) 185.71 (36.83) 191.83 (36.94) 190.50 (33.59) 0.786 191.16 (32.40) 180.05 (27.49) 199.80 (32.87) 0.316
TG (mg/dL) 113.26 (43.56) 87.27 (34.73) 100.85 (34.30) 0.06 130.49 (70.65) 131.72 (62.35) 155.60 (53.83) 0.732
Glucose (mg/dL) 91.08 (10.34) 88.38 (12.08) 95.00 (11.02) 0.235 93.95 (12.82) 96.94 (25.40) 113.80 (39.96) 0.05
Insulin (U/mL) 18.36 (9.25) 11.81 (6.77) 15.73 (10.43) 0.329 14.16 (7.63) 13.81 (6.76) 21.16 (11.06) 0.139
HOMA-IR 4.22 (2.18) 2.66 (1.66) 3.68 (2.57) 0.531 3.22 (1.77) 3.38 (1.99) 5.50 (2.52) 0.035
QUICKI 0.31 (0.02) 0.34 (0.03) 0.32 (0.03) 0.116 0.32 (0.02) 0.32 (0.02) 0.30 (0.02) 0.143
α-MSH (ng/L) 168.14 (97.74) 274.41 (213.43) 271.55 (231.49) 0.010 226.61 (172.86) 201.94 (122.25) 299.61 (249.29) 0.533
AgRP (pg/mL) 24.12 (9.52) 33.94 (21.69) 34.86 (27.11) 0.019 33.93 (19.92) 31.5 (13.04) 38.80 (29.97) 0.789
  1. Italic values indicate significance of P value (P < 0.05)
  2. TC total cholesterol, TG triglyceride, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, HOMA-IR homeostatic model assessment for insulin resistance, QUICKI quantitative insulin sensitivity check index, α-MSH alpha-melanocyte-stimulating hormone, AgRP, agouti-related peptide; all variables data are presented based on mean (SD)
  3. *P values based on ANCOVA after adjustment for age