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Table 2 Comparison of clinical and laboratory parameters of participants according to CART rs2239670 genotypes

From: Cocaine and amphetamine-regulated transcript prepropeptide gene (CARTPT) polymorphism interacts with Diet Quality Index-International (DQI-I) and Healthy Eating Index (HEI) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals

 

Women (n = 140)

Men (n = 147)

GG (n = 90)

AG (n = 28)

AA (n = 22)

P*

GG (n = 109)

AG (n = 30)

AA (n = 8)

P*

LDL-C (mg/dL)

116.66 (34.00)

124.32 (37.89)

122.82 (28.47)

0.645

122.07 (29.43)

114.48 (24.87)

125.68 (27.63)

0.563

HDL (mg/dL)

46.40 (9.37)

50.05 (7.87)

47.50 (10.25)

0.347

43.00 (6.89)

39.22 (6.87)

43.00 (6.74)

0.122

Cholesterol (mg/dL)

185.71 (36.83)

191.83 (36.94)

190.50 (33.59)

0.786

191.16 (32.40)

180.05 (27.49)

199.80 (32.87)

0.316

TG (mg/dL)

113.26 (43.56)

87.27 (34.73)

100.85 (34.30)

0.06

130.49 (70.65)

131.72 (62.35)

155.60 (53.83)

0.732

Glucose (mg/dL)

91.08 (10.34)

88.38 (12.08)

95.00 (11.02)

0.235

93.95 (12.82)

96.94 (25.40)

113.80 (39.96)

0.05

Insulin (U/mL)

18.36 (9.25)

11.81 (6.77)

15.73 (10.43)

0.329

14.16 (7.63)

13.81 (6.76)

21.16 (11.06)

0.139

HOMA-IR

4.22 (2.18)

2.66 (1.66)

3.68 (2.57)

0.531

3.22 (1.77)

3.38 (1.99)

5.50 (2.52)

0.035

QUICKI

0.31 (0.02)

0.34 (0.03)

0.32 (0.03)

0.116

0.32 (0.02)

0.32 (0.02)

0.30 (0.02)

0.143

α-MSH (ng/L)

168.14 (97.74)

274.41 (213.43)

271.55 (231.49)

0.010

226.61 (172.86)

201.94 (122.25)

299.61 (249.29)

0.533

AgRP (pg/mL)

24.12 (9.52)

33.94 (21.69)

34.86 (27.11)

0.019

33.93 (19.92)

31.5 (13.04)

38.80 (29.97)

0.789

  1. Italic values indicate significance of P value (P < 0.05)
  2. TC total cholesterol, TG triglyceride, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, HOMA-IR homeostatic model assessment for insulin resistance, QUICKI quantitative insulin sensitivity check index, α-MSH alpha-melanocyte-stimulating hormone, AgRP, agouti-related peptide; all variables data are presented based on mean (SD)
  3. *P values based on ANCOVA after adjustment for age