Translational value of IDH1 and DNA methylation biomarkers in diagnosing lung cancers: a novel diagnostic panel of stage and histology-specificity

Table 4 Subgroup analysis of the 3-biomarker model

Subgroups	Variables	AUC	S.E.	95% CI	p value
≤ 5 cm	shox2	0.643	0.0397	0.571–0.710	< 0.0001
	ep4	0.619	0.0377	0.547–0.688	0.0007
	idh1	0.79	0.0335	0.726–0.845	0.0903*
	panel	0.832	0.0297	0.771–0.881	–
>5 cm	shox2	0.958	0.0218	0.898–0.988	0.6006*
	ep4	0.924	0.0396	0.853–0.968	0.0038
	idh1	0.731	0.0552	0.632–0.815	< 0.0001
	panel	0.967	0.016	0.909–0.992	–
Ade	shox2	0.629	0.0413	0.555–0.699	< 0.0001
	ep4	0.618	0.0389	0.544–0.689	< 0.0001
	idh1	0.791	0.0342	0.724–0.847	0.2415*
	panel	0.819	0.0315	0.756–0.872	–
non-Ade	shox2	0.907	0.0355	0.837–0.954	0.0563*
	ep4	0.838	0.0473	0.755–0.902	0.0034
	idh1	0.748	0.0467	0.656–0.826	< 0.0001
	panel	0.963	0.0161	0.909–0.990	–

shox2 short stature homeobox 2 gene, ep4 prostaglandin E2 receptor 4 gene (PTGER4), idh1 isocitrate dehydrogenase 1, AUC area under the curve, S.E. standard error, 95% CI 95% confidence interval
* Nonsignificant difference

ISSN: 1479-5876