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Table 7 Associations between miR expression changes and MRD parameters or risk factors

From: Circulating microRNAs as minimal residual disease biomarkers in childhood acute lymphoblastic leukemia

miR Time points Fold change Independent variable Patient subgroup Pearson’s r Adjusted p
miR-128-3p Day 8 vs day 0 0.107 Flow cytometry MRD in day 15 bone marrow Whole cohort 0.88 2.71*10−4
miR-222-3p Day 8 vs day 0 0.267 Flow cytometry MRD in day 15 bone marrow Whole cohort 0.81 2.99*10−3
miR-128-3p Day 8 vs day 0 0.149 Flow cytometry MRD in day 15 bone marrow Normal karyotypea 0.99 7.53*10−4
miR-222-3p Day 8 vs day 0 0.270 Flow cytometry MRD in day 15 bone marrow Normal karyotypea 0.97 2.74*10−2
miR-222-3p Day 8 vs day 0 0.190 Absolute peripheral blast count on day 8 t(12;21) 0.96 4.63*10−2
miR-181b-5p Day 33 vs day 0 0.061 Absolute lymphocyte count on day 33 Normal karyotypea 0.95 2.98*10−2
miR-222-3p Day 33 vs day 0 0.156 Absolute lymphocyte count on day 33 Normal karyotypea 0.94 3.87*10−2
  1. In these analyses, the dependent variable is the normalized miR expression change between the time points compared, all measured in PB PFP. Fold change indicates change in the normalized miR expression between the two time points, the median of these values are provided. Pearson’s r indicates the correlation between the dependent and the independent variables. Adjusted p refers to the statistical significance of the Pearson’s correlation
  2. aNormal karyotype: no alteration on FISH, DNA index diploid and cytogenetics normal or unsuccessful