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Table 7 Associations between miR expression changes and MRD parameters or risk factors

From: Circulating microRNAs as minimal residual disease biomarkers in childhood acute lymphoblastic leukemia

miRTime pointsFold changeIndependent variablePatient subgroupPearson’s rAdjusted p
miR-128-3pDay 8 vs day 00.107Flow cytometry MRD in day 15 bone marrowWhole cohort0.882.71*10−4
miR-222-3pDay 8 vs day 00.267Flow cytometry MRD in day 15 bone marrowWhole cohort0.812.99*10−3
miR-128-3pDay 8 vs day 00.149Flow cytometry MRD in day 15 bone marrowNormal karyotypea0.997.53*10−4
miR-222-3pDay 8 vs day 00.270Flow cytometry MRD in day 15 bone marrowNormal karyotypea0.972.74*10−2
miR-222-3pDay 8 vs day 00.190Absolute peripheral blast count on day 8t(12;21)0.964.63*10−2
miR-181b-5pDay 33 vs day 00.061Absolute lymphocyte count on day 33Normal karyotypea0.952.98*10−2
miR-222-3pDay 33 vs day 00.156Absolute lymphocyte count on day 33Normal karyotypea0.943.87*10−2
  1. In these analyses, the dependent variable is the normalized miR expression change between the time points compared, all measured in PB PFP. Fold change indicates change in the normalized miR expression between the two time points, the median of these values are provided. Pearson’s r indicates the correlation between the dependent and the independent variables. Adjusted p refers to the statistical significance of the Pearson’s correlation
  2. aNormal karyotype: no alteration on FISH, DNA index diploid and cytogenetics normal or unsuccessful