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Table 8 Clinical characteristics of CRC involving the microbiological study

From: Analysis of prognosis, genome, microbiome, and microbial metabolome in different sites of colorectal cancer

 

Rectum group

Sigmoid colon group

p-value

Cases, n

15

13

–

Age (years)

59.53 ± 12.14

68.15 ± 9.75

0.051

Males, n

9

7

0.743

BMI (kg/m2)

22.96 ± 3.03

22.90 ± 2.91

0.956

Known hypertension, n

4

6

0.283

Known diabetes, n

2

0

0.172

Long-term Smoking history, n

3

3

0.843

Long-term drinking history, n

3

2

0.750

Red blood cells (1012/L)

4.38 ± 0.67

4.16 ± 0.51

0.336

Haemoglobin (g/L)

132.20 ± 21.55

124.69 ± 19.79

0.349

white blood cells (109/L)

5.53 ± 1.38

4.88 ± 1.38

0.225

Blood platelet (109/L)

228.73 ± 77.88

192.54 ± 52.56

0.168

Haematocrit

0.40 ± 0.06

0.40 ± 0.05

0.321

Mean red blood cell haemoglobin content

30.20 ± 1.90

29.65 ± 3.35

0.594

Mean corpuscular-haemoglobin concentration

331.40 ± 12.02

329.08 ± 13.85

0.639

Mean red blood cell volume

91.12 ± 5.27

89.90 ± 7.50

0.619

Red blood cell distribution width

12.78 ± 0.64

13.35 ± 2.12

0.332

Alanine transaminase (U/L)

15.97 ± 8.23

15.05 ± 5.40

0.732

Glutamic oxaloacetic transaminase (U/L)

18.93 ± 2.88

18.39 ± 2.18

0.585

Total protein (g/L)

66.19 ± 7.24

65.92 ± 5.39

0.910

Albumin (g/L)

37.78 ± 4.35

37.40 ± 3.86

0.810

Total bilirubin (g/L)

13.57 ± 7.79

13.00 ± 5.70

0.828

Direct bilirubin (g/L)

5.01 ± 2.62

4.60 ± 1.59

0.631

Creatinine (μmol/L)

70.61 ± 15.91

72.52 ± 15.60

0.753

Urea nitrogen (mmol/L)

5.56 ± 2.11

4.39 ± 1.43

0.101

Glucose (mmol/L)

5.13 ± 0.98

4.93 ± 0.60

0.536

CA125

10.31 ± 2.93

10.96 ± 3.17

0.579

CA153

8.09 ± 4.71

6.88 ± 3.26

0.444

CA724

2.21 ± 1.56

2.36 ± 2.20

0.843

CA199

9.12 ± 9.28

38.19 ± 50.70

0.038

CEA

19.62 ± 37.26

10.56 ± 15.23

0.421

Cytokeratin 19 fragment

1.61 ± 0.60

2.03 ± 0.84

0.137

Neuron specific enolase

11.69 ± 3.07

9.85 ± 2.09

0.102

Squamous cell carcinoma associated antigen

0.83 ± 0.59

0.73 ± 0.27

0.598

Alpha fetoprotein

3.20 ± 1.93

2.37 ± 0.74

0.154

Ki-67 (%)

61.33 ± 11.87

65.38 ± 13.91

0.413

TMN stage

 Stage II

13

8

0.126

 Stage III

2

5

  1. A total of 28 CRC patients including 15 cases of rectal cancer and 13 cases of sigmoid cancer in Huzhou Central Hospital from January 2018 to August 2018 were recruited in the microbiology and microbial metabolites study after screening and identification. Smoking and drinking history over the course of 1 year were recruited. The TMN stages are according to AJCC. Patient personal information, serological indicators, and Ki-67 indexes were collected from the hospital’s HIS system after the consent of the patients