Complementary biobank of rodent tissue samples to study the effect of World Trade Center exposure on cancer development

Table 3 Description of Mount Sinai bio-samples from WTC dust-exposed BL6 mice

Bio-sample	Genotype	Storage format
Genetic modification in prostate
Prostate^a	Pten ^{− /−}	Frozen + paraffin
Lung	Pten ^{+ /+}	Frozen + paraffin
Bladder	Pten ^{+ /+}	Frozen
Thyroid	Pten ^{+ /+}	Frozen
Spleen	Pten ^{+ /+}	Frozen
Whole blood	Pten ^{+ /+}	Frozen
Serum	Pten ^{+ /+}	Frozen
Genetic modification in lung
Prostate	Pten ^{+ /+}	Frozen + paraffin
Lung^b	Pten ^{− /−}	Frozen + paraffin
Bladder	Pten ^{+ /+}	Frozen
Thyroid	Pten ^{+ /+}	Frozen
Spleen	Pten ^{+ /+}	Frozen
Whole blood	Pten ^{+ /+}	Frozen
Serum	Pten ^{− /−}	Frozen

All mice were intranasally-instilled, 3 doses (4 mg) every other day. Time to harvest was 1–6 months post-final exposure in mice with genetically-modified prostates, and > 4 months post-final exposure in mice with genetically-modified lung tissue
^a Pb-Cre+; PtenLL GEM model
^b Mice treated with (1) WTC dust, (2) PBS, (3) WTC dust + Ad-cre, or (4) PBS + Ad-cre

ISSN: 1479-5876