|
MiRNA
|
Molecular subtype
|
Mean (SD)
|
Contrasts
|
p*
|
|---|
|
miR-17-5p
|
Luminal A
|
− 5.49 (0.73)
|
Luminal A vs others
|
0.066
|
|
Luminal B
|
− 4.93 (1.43)
|
Luminal B vs others
|
0.65
|
|
HER2+
|
− 5.03 (1.70)
|
HER2+ vs others
|
0.58
|
|
Triple-negative
|
− 3.26 (0.95)
|
Triple-negative vs others
|
0.0025
|
|
miR-20a-5p
|
Luminal A
|
1.72 (0.68)
|
Luminal A vs others
|
0.066
|
|
Luminal B
|
2.21 (1.18)
|
Luminal B vs others
|
0.67
|
|
HER2+
|
2.15 (1.19)
|
HER2+ vs others
|
0.65
|
|
Triple-negative
|
3.45 (1.03)
|
Triple-negative vs others
|
0.0053
|
|
miR-92a-3p
|
Luminal A
|
1.44 (0.74)
|
Luminal A vs others
|
0.070
|
|
Luminal B
|
1.75 (1.00)
|
Luminal B vs others
|
0.58
|
|
HER2+
|
1.89 (0.97)
|
HER2+ vs others
|
0.85
|
|
Triple-negative
|
2.87 (0.90)
|
Triple-negative vs others
|
0.0073
|
|
miR-106b-5p
|
Luminal A
|
− 0.014 (0.55)
|
Luminal A vs others
|
0.12
|
|
Luminal B
|
0.30 (1.11)
|
Luminal B vs others
|
0.65
|
|
HER2+
|
0.54 (1.44)
|
HER2+ vs others
|
0.91
|
|
Triple-negative
|
1.10 (0.84)
|
Triple-negative vs others
|
0.070
|
|
miR-93-5p
|
Luminal A
|
1.20 (0.73)
|
Luminal A vs others
|
0.070
|
|
Luminal B
|
1.78 (0.97)
|
Luminal B vs others
|
0.93
|
|
HER2+
|
1.85 (1.21)
|
HER2+ vs others
|
0.91
|
|
Triple-negative
|
2.37 (1.03)
|
Triple-negative vs others
|
0.085
|
- Expression levels are presented as mean (standard deviation) of normalized PCR quantification cycle (Cq) values based on the average of the normalizer assay detected in all samples and the formula: normalized Cq = average Cq (all samples) − assay Cq (sample). Negative PCR expression values indicate lower expression levels compared to the normalizer
- * False discovery rate (FDR) adjusted p-value for contrast tests comparing miRNA expression levels in one molecular subtype of cancers to the other cancers grouped together. E indicates exponential number
