Simul. TTP

Clinic. TTP


0–90 days

90–150 days

150–365 days

No progressive disease during followup


0–90 days

8 (14.8%)

0 (0%)

2 (3.7%)

0 (0%)

90–150 days

0 (0%)

3 (5.6%)

0 (0%)

0 (0%)

150–365 days

0 (0%)

0 (0%)

2 (3.7%)

0 (0%)

No progressive disease during followup

2 (3.7%)

1 (1.85%)

1 (1.85%)

35 (64.8%)

 The simulated TTP (Simul.) was obtained by fitting the simulations of the mathematical model in Eq. (1) to the clinical results (Clinic.). The cells in the table include the number of cases and the percentage of the total number of patients in the cohort, (in brackets; N = 54), which satisfy one of the six possible outcomes described in the “Methods” section. The italicized numbers represent the number of cases, for which the algorithm correctly predicted whether progression will occur, and correctly predicted the time interval during which progression would occur; Cohen’s κ = 0.773