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Table 2 Cytokines and inflammation/oxidation-related genes in leukocytes of ASD and TD children

From: Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder

Inflammation/oxidation-related genes Fold change (ratio ASD/TD) 95% confidence interval (CI) Two-sided p value for ASD vs TD difference Correlation with total CARS score Correlation with hyperactivity Correlation with stereotypies Correlation with cognitive level
AHR 0.77 0.471–1.281 NS p = 0.0025
r = 0.70
pFDR = 0.12
NS NS NS
HSP70i 1.787 1.227–2.602 p < 0.01 NS NS NS NS
IL6 2.204 1.246–3.898 p < 0.01 NS NS NS NS
IL10 1.187 0.690–2.043 NS p = 0.0246
r = 0.55
pFDR = 0.17
p = 0.0128
r = 0.6
pFDR =0.12
NS p = 0.0377
r = 0.49
pFDR = 0.23
IL12A 1.537 0.893–2.646 NS p = 0.0043
r = 0.67
pFDR = 0.13
NS p = 0.0197
r = 0.58
pFDR = 0.16
NS
IL1 beta 1.339 0.779–2.303 NS p = 0.007
r = 0.64
pFDR = 0.11
NS NS NS
COX1 1.025 0.785–1.337 NS NS NS NS NS
COX2 1.312 0.788–2.184 NS p = 0.0435
r = 0.51
pFDR = 0.21
NS NS NS
PRX2 1.038 0.867–1.243 NS NS NS p = 0.0111
r = 0.62
pFDR = 0.13
NS
PRX5 0.983 0.884–1.092 NS NS NS NS NS
STAT3 0.952 0.382–2.376 NS NS NS NS NS
TNF-alpha 0.999 0.567–1.759 NS NS NS NS NS
  1. Statistically significant correlations are underlined
  2. ASD Autism Spectrum Disorders, TD typically developing, CARS Childhood Autism Rating Scale, AHR Aryl Hydrocarbon Receptor, HSP70i Heat Shock Protein 70, inducible form, IL interleukin, COX cyclooxygenase, PRX peroxiredoxin, STAT3 Signal Transducer and Activator of Transcription 3, TNF-alpha Tumor Necrosis Factor-alpha, NS not significant, r correlation coefficient