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Table 3 Univariate and multivariate analyses of OS and BCSS for the MBC variables included in the study after PSM

From: The role of radiotherapy in metaplastic breast cancer: a propensity score-matched analysis of the SEER database

Characteristics Univariate Multivariate
OS BCSS OS BCSS
HR (95% CI) P-value HR (95% CI) P-value HR (95% CI) P-value HR (95% CI) P-value
Age at diagnosis (< 60 as ref.)
 ≥ 60 1.49 (1.20–1.85) < 0.001 1 (0.78–1.289) 0.987 1.6 (1.26–2.05) < 0.001 1.23 (0.94–1.62) 0.138
Race (white as ref.)
 Black 1.18 (0.89–1.60) 0.243 1.22 (0.89–1.68) 0.22 1.03 (0.77–1.39) 0.842 0.95 (0.68–1.32) 0.755
 Others 0.96 (0.61–1.49) 0.842 1.07 (0.66–1.73) 0.798 1.09 (0.69–1.71) 0.723 1.06 (0.65–1.74) 0.813
Marital status (single as ref.)
 Married 0.7 (0.53–0.94) < 0.05 0.62 (0.46–0.84) < 0.01 0.68 (0.50–0.91) 0.01 0.68 (0.49–0.95) < 0.05
Grade (G1 as ref.)
 G2 0.98 (0.48–2.01) 0.958 0.8 (0.33–1.93) 0.617 0.96 (0.47–1.98) 0.918 0.8 (0.33–1.94) 0.62
 G3 1.58 (0.84–2.97) 0.155 1.8 (0.85–3.82) 0.127 1.23 (0.65–2.32) 0.529 1.26 (0.59–2.68) 0.557
 G4 1.34 (0.64–2.80) 0.439 1.58 (0.67–3.77) 0.299 1.34 (0.64–2.81) 0.443 1.44 (0.60–3.44) 0.411
ER status (negative as ref.)
 Positive 0.82 (0.60–1.14) 0.239 0.84 (0.59–1.21) 0.353 0.83 (0.57–1.21) 0.331 0.76 (0.50–1.15) 0.19
PR status (negative as ref.)
 Positive 0.63 (0.43–0.93) < 0.05 0.77 (0.51–1.15) 0.204 0.67 (0.43–1.04) 0.074 0.89 (0.56–1.42) 0.627
Stage T (≤ 5 cm as ref.)
 > 5 cm 3.84 (3.08–4.78) < 0.001 4.41 (3.44–5.66) < 0.001 2.99 (2.31–3.86) < 0.001 3.18 (2.39–4.24) < 0.001
Stage N (N0 as ref.)
 N1 1.56 (1.20–2.05) 0.001 2.02 (1.51–2.71) < 0.001 1.21 (0.91–1.61) 0.191 1.43 (1.04–1.95) < 0.05
 N2 2.91 (2.02–4.20) < 0.001 3.29 (2.19–4.95) < 0.001 1.84 (1.24–2.72) < 0.01 1.82 (1.17–2.82) < 0.01
 N3 3.27 (2.14–5.00) < 0.001 4.04 (2.55–6.40) < 0.001 2.2 (1.39–3.48) 0.001 2.41 (1.46–3.98) 0.001
Breast operation (lumpectomy as ref.)
 Mastectomy 2.6 (2.04–3.31) < 0.001 3.18 (2.38–4.25) < 0.001 1.46 (1.08–1.98) < 0.05 1.52 (1.06–2.18) < 0.05
Chemotherapy (not done/unknown as ref.)
 Done 0.84 (0.67–1.05) 0.12 1.35 (1.02–1.80) < 0.05 0.75 (0.58–1.00) < 0.05 1.08 (0.79–1.48) 0.617
Radiotherapy (not done as ref.)
 Done 0.62 (0.50–0.77) < 0.001 0.65 (0.51–0.84) < 0.001 0.64 (0.51–0.80) < 0.001 0.64 (0.50–0.83) 0.001
Axilla LN operation (SLNB as ref.)
 ALND 1.89 (1.49–2.39) < 0.001 2.22 (1.68–2.92) < 0.001 1.17 (0.89–1.54) 0.254 1.16 (0.85–1.60) 0.347
  1. SLNB sentinel lymph node biopsy, ALND axillary lymph node dissection
  2. Significant results are in italic