Identification of key DNA methylation-driven genes in prostate adenocarcinoma: an integrative analysis of TCGA methylation data

Table 4 Pathway enriched by the 266 DNA methylation driven genes

Pathway	External_id	Members_input_overlap	p-value	q-value	Size
Drug metabolism—cytochrome P450	hsa00982	AOX1; GSTM1; GSTM2; ALDH3A1; MAOB; GSTP1; ALDH1A3	6.59E−05	0.003828899	70
Phenylalanine metabolism	hsa00360	PAH; MAOB; ALDH3A1; ALDH1A3	9.23E−05	0.003828899	17
Histidine metabolism	hsa00340	MAOB; ALDH3A1; ALDH2; ALDH1A3	0.000320403	0.008864472	23
Glutathione metabolism	hsa00480	GSTM1; GSTM2; GPX3; GSTP1; GPX7	0.00114281	0.023713299	54
Tyrosine metabolism	hsa00350	AOX1; ALDH3A1; ALDH1A3; MAOB	0.001836818	0.030491186	36
Tryptophan metabolism	hsa00380	MAOB; HAAO; ALDH2; AOX1	0.002722806	0.037665486	40
Metabolism of xenobiotics by cytochrome P450	hsa00980	GSTM1; GSTM2; ALDH3A1; GSTP1; ALDH1A3	0.00433977	0.051457275	74
Chemical carcinogenesis	hsa05204	GSTM1; GSTM2; ALDH3A1; GSTP1; ALDH1A3	0.007094498	0.073605418	82

ISSN: 1479-5876