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Table 1 Pathological functions of MMPs associated with collagen in cancer

From: The role of collagen in cancer: from bench to bedside

Subtype of MMPs Associated collagen Pathological functions of collagen References
MMP-1 COLI Regulated to facilitate melanoma cell growth and invasion [227, 228]
COLIV Regulated to foster breast cancer cell invasion in response to prolactin [229]
MMP-2 COLI Modulating MMP-2 activation in osteosarcoma [230]
COL4A2 Modulating MMP-2 activation and activity in liver cancer [231]
COLI and COLIV Regulated by the knockdown of MMP-2 to induce cancer metastases [232, 233]
Collagen organization Regulated to enhance malignant glioma recurrence and resistance to vemurafenib [234, 235]
MMP-3 COLI Regulated to induce mammary epithelial cells invasion and morphogenesis with chaperone heat-shock protein 90 [236]
COL11A1 Regulated to promote ovarian cancer progression [237]
MMP-7 COLI Both to predict the prognosis of opisthorchiasis-associated cholangiocarcinoma [238]
MMP-9 COLI Degraded in invasive melanoma fronts [239]
  COLI Potentiated in Opisthorchis viverrini-induced cholangiocarcinogenesis [240]
COLIV Degraded to facilitate venous invasion in PDAC [241]
MMP-10 COLI Regulated by TGF-β in keratinocytes to promote invasion [242]
MMP-14 COLI Increased to promote fibrosis by TGF-β signaling in PDAC [243]
COLI Modulating MMP-2 and MMP-14 activation via β1 integrin [244]
COLI Regulated to prevent apoptosis to promote luminal-like breast cancer progression [245]
COLI Sustained activation of MMP-14 with EGFR at the cell surface enhances invasion, whereas growth within three-dimensional collagen is inhibited [246]
MMP-16 COLI Supported around melanoma cells to enhance lymphatic invasion [247]
MMP-28 COLII interacted to more adhesion and less migratory [248]