Table 2 GO and KEGG pathway enrichment analysis of DEGs in the high-ESR2 group
Category | Term | Count | p value | Genes |
|---|---|---|---|---|
BP | Cell adhesion | 6 | 3.6E−02 | CLCA2, COL7A1, PKP1, ADAM23, DSC3, COL4A6 |
BP | Embryonic limb morphogenesis | 5 | 1.9E−05 | HOXC10, DLX6, DLX5, BMP7, HOXD10 |
BP | Epithelial cell differentiation | 5 | 1.7E−04 | RHCG, DLX6, DLX5, UPK1B, BMP7 |
CC | Extracellular exosome | 20 | 1.5E−02 | COCH, GDA, KRT6B, LGALS7, KRT13, CALB1, A2ML1, LGALS7B, CD19, KRT74, NEB, PKP1, KRT5, RHCG, CALML3, DSG3, UPK1B, MS4A1, SPRR3, SERPINB13 |
CC | Integral component of plasma membrane | 12 | 2.7E−02 | EPHA7, CLCA2, CD19, SLCO1A2, RHCG, ADAM23, PTPRZ1, GABRA3, CDHR1, NTRK2, UPK1B, MS4A1 |
CC | Keratin filament | 4 | 7.8E−03 | KRT74, KRT6B, KRT5, KRT13 |
MF | Calcium ion binding | 8 | 3.1E−02 | CALML3, DSG3, CDHR1, NELL2, DSC3, CALB1, PCDH19, CACNA1B |
MF | Sequence-specific DNA binding | 7 | 2.2E−02 | HOXC10, DLX6, SOX2, FOXE1, DMRT2, HOXD10, HOXD11 |
MF | Structural molecule activity | 6 | 3.8E−03 | KRT74, KRT5, SPRR2A, UPK1B, SPRR3, KRT13 |
KEGG | GABAergic synapse | 3 | 3.8E−02 | GABRA3, HAP1, CACNA1B |