Fig. 5
From: Medulloblastoma rendered susceptible to NK-cell attack by TGFβ neutralization
UCB-derived NK cells expressing TGF-β DNR have increased expression of CCR2. a Example flow for a paired transduced and non-transduced NK cell line showing the effects of medulloblastoma-conditioned media on the expression of CCR2. b Summary MFI for CCR2 expression in transduced and nontransduced cells (mean CCR2 MFI 1639.29 ± 215 untransduced NK vs. 1522 ± 409 TGF-β DNR expressing NK, n = 7, p = 0.94) in the presence and absence of medulloblastoma-conditioned media (mean CCR2 MFI 826 ± 117 untransduced NK + MB supernatant, n = 7, p = 0.0156; mean CCR2 MFI 1028 ± 108 transduced NK + MB supernatant, n = 7, p = 0.22). c Changes in percent CCR2 CCR2 expression in transduced (7.1 ± 3.077% without MB vs. 3.271 ± 1.094 with MB n = 8, p = ns) and nontransduced (2.1 ± 0.540 without MB vs. 0.979 ± 0.168 with MB, n = 8, p = 0.0361) cells in the presence and absence of medulloblastoma-conditioned media. Error bars refer to standard error of the mean