Fig. 4

TREM2 deficiency down-regulated MCP-1 expression of adipocytes in mice of HFD. WT and TREM2^−/− mice of C57BL/6 of 6 weeks were fed with HFD for 12 weeks. a Circulating levels of MCP-1 of WT and TREM2^−/− mice after 12 weeks of HFD feeding (N = 19/group). b MCP-1 expression levels of adipose tissue of WT and TREM2^−/− mice after 12 weeks of HFD feeding (N = 8/group). c MCP-1 expression levels of macrophages of WT and TREM2^−/− mice after 12 weeks of HFD feeding (N = 8/group). d MCP-1 expression levels of adipocytes of WT and TREM2^−/− mice after 12 weeks of HFD feeding (N = 8/group). Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001