Fig. 1

TREM2^−/− mice exhibited increased obesity, insulin resistance and altered adipose tissue remodeling under HFD. WT and TREM2^−/− mice of C57BL/6 of 6 weeks were fed with CFD or HFD for 12 weeks. a Bodyweight of WT and TREM2^−/− mice under CFD or HFD feeding (N = 16/group). b GTT and c AUC of WT and TREM2^−/− mice after 12 weeks of HFD feeding (N = 9/group). d ITT and e AUC of WT and TREM2^−/− mice after 12 weeks of HFD feeding (N = 7/group). f Protein analysis of Akt and p-Akt in total adipose tissue of HFD feeding mice. g Epididymal fat pad mass and h proportion of bodyweight of WT and TREM2^−/− mice after 12 weeks of CFD (N = 5/group) or HFD (N = 10/group) feeding. i Representative images of H&E staining of epididymal adipose tissue of WT and TREM2^−/− mice after 12 weeks of CFD or HFD feeding. Original magnification is ×100 and ×400 (within box at bottom right), scale bar = 200 μm. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001