Fig. 2

The abnormal glucose metabolism in GH-PA. a The stacked bars below show a summary of the joint evidence from enrichment analysis and topology analysis. The top 20 enriched pathway was showed. Blue bar (enrichment) shows joint-enrichment of both the differentially expressed proteins and metabolites in a particular pathway. Orange bar (topology) indicates a given protein or metabolite plays an important role in a biological response based on its position within a pathway. b The metabolites and proteins in glycolysis/gluconeogenesis pathway, pentose phosphate pathway and citrate cycle pathway was identified in GH adenoma