Skip to main content

Table 3 Consistency between variant patterns in paired primary and metastatic lesions: A—classified (pathogenic/likely pathogenic and benign/likely benign) variants, B—all variants

From: Mutational concordance between primary and metastatic melanoma: a next-generation sequencing approach

Paired tissue types No. of samples Cases with consistent mutation pattern (%) Cases with discrepant mutation pattern (%)
A. Pathogenic/likely pathogenic + benign/likely benign variants
 Primary vs. lymph node metastasis 31 23 (74) 8 (26)
 Primary vs. visceral metastasis 18 8 (44) 10 (56)
 Primary vs. metastasis 49 31 (63) 18 (37)
B. All variants
 Primary vs. lymph node metastasis 31 9 (29) 22 (71)
 Primary vs. visceral metastasis 18 3 (17) 15 (83)
 Primary vs. metastasis 49 12 (24) 37 (76)