Table 1 Demographic, clinical and pathological features of the patients included in the study
Characteristics | Global cohort (41 cases) | Discovery cohort (30 cases) | Validation cohort (11 cases) | p-value |
|---|---|---|---|---|
Male sex, n (%) | 28 (68.3) | 15 (53.6) | 11 (100) | 0.003 |
Age, (mean ± SD), years | 55 ± 12.7 | 53.9 ± 13.2 | 58 ± 11.1 | 0.324 |
IPMD, (mean ± SD), months | 24.3 ± 26.4 | 25.3 ± 29.2 | 21.1 ± 13.4 | 0.523 |
Melanoma type, n (%) | ||||
 NM | 12 (29.3) | 8 (26.7) | 4 (36.4) | 0.828 |
 SSM | 28 (68.3) | 21 (70) | 7 (63.6) | 0.993 |
 LMM | 1 (2.4) | 1 (3.3) | 0 (0) | 1.000 |
Melanoma site, n (%) | ||||
 A. Primitive | ||||
  Head | 2 (4.9) | 2 (6.7) | 0 (0) | 1.000 |
  Neck | 3 (7.3) | 2 (6.7) | 1 (9.1) | 1.000 |
  Trunk | 19 (46.3) | 13 (43.3) | 6 (54.5) | 0.776 |
  Upper limbs | 3 (7.3) | 2 (6.7) | 1 (9.1) | 1.000 |
  Lower limbs | 14 (34.1) | 11 (36.7) | 3 (27.3) | 1.000 |
 B. Metastasis | 49 (100) | 36 (73.5) | 13 (26.5) | 0.853 |
  Lymph nodes | 31 (64.6) | 23 (63.9) | 8 (66.7) | |
  Visceral | 18 (35.4) | 13 (36.1) | 5 (33.3) | |
Number of mitosis per smm (mean ± SD) | 3.4 ± 3.1 | 4.1 ± 3.0 | 1.6 ± 2.5 | 0.003 |
Breslow thickness, (mean ± SD) | 3.8 ± 2.4 | 4.0 ± 2.4 | 3.2 ± 1.4 | 0.566 |
Ulceration, n (%) | 18 (43.9) | 12 (40) | 6 (54.5) | 0.634 |
Initial T/N stage, n (%) | ||||
 A. T stage | ||||
  T1 | 2 (4.9) | 2 (6.7) | 0 | 1.000 |
  T2 | 7 (17.1) | 5 (16.7) | 2 (18.2) | 1.000 |
  T3 | 19 (46.3) | 13 (43.3) | 6 (54.5) | 0.776 |
  T4 | 13 (31.7) | 10 (33.3) | 3 (27.3) | 1.000 |
 B. N stage | ||||
  N0 | 8 (19.5) | 6 (20.0) | 2 (18.2) | 1.000 |
  N1 | 16 (39.0) | 11 (36.7) | 5 (45.4) | 0.723 |
  N2 | 13 (31.7) | 9 (30.0) | 4 (36.4) | 1.000 |
  N3 | 4 (9.8) | 4 (13.3) | 0 | 0.559 |