Fig. 3

SP-8356 inhibits neointimal hyperplasia and prevents arterial stiffness. a Representative cross-sections of carotid arteries stained with hematoxylin–eosin (H&E). Scale bar, 100 μm. Magnification, × 100. b Ratios of neointima and media areas. Vehicle (n = 9), rosuvastatin (n = 6), and SP-8356 (n = 9). Data are presented as a box plot ± range. ^**p < 0.01, ^***p < 0.001. c Arterial stiffness was assessed by measuring pulse wave velocity (PWV). Normal (n = 15), vehicle (n = 9), rosuvastatin (n = 6), and SP-8356 (n = 6). Data are presented as box plot ± range. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001