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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47phox phosphorylation, NADPH oxidase activation and MuRF1 expression

Fig. 7

Inhibition of NADPH oxidase with apocynin prevents oxidative stress and myocardial abnormalities in tail-suspended mice. Tail-suspended mice were given apocynin or vehicle in drinking water for 28 days. Oxidative stress was assessed by measuring ROS production (a), MDA production (b) and protein carbonyl content (c) in mouse hearts. The heart weight/tibia length ratio (d) and cardiomyocyte cross-sectional area (e, f) were determined. e A representative staining of WGA in heart tissue sections. f Cardiomyocyte cross-sectional area. Myocardial dysfunction was assessed by ejection fraction (EF)% (g) and fraction shortening (FS)% (h). Data are mean ± SD, n = 6 in each group. *P < 0.05 vs. Sham + Vehicle and P < 0.05 vs. TS + Vehicle

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