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Table 2 Effects of pentoxifylline (PTX, a cytokine blocker, 30 mg/kg, IP) treatment on metabolic and anatomic data in rats after HFD consumption for 17 weeks

From: Adipose afferent reflex is enhanced by TNFα in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats

Parameters Control Control + PTX OH OH + PTX
BW (g) 559 ± 41 548 ± 43 688 ± 51* 645 ± 49
Plasma glucose (mg/dl) 126 ± 12 122 ± 11 147 ± 16 142 ± 15
Plasma insulin (ng/ml) 1.51 ± 0.3 1.48 ± 0.3 3.12 ± 0.31* 2.09 ± 0.27#
Plasma cholesterol (mg/dl) 43.1 ± 4.1 42.0 ± 3.9 61.2 ± 6.5* 58.3 ± 5.7
Plasma triglyceride (mg/dl) 66.9 ± 6.6 65.8 ± 7.2 92.6 ± 9.3* 85.2 ± 7.9
HW (mg) 1609 ± 91 1610 ± 112 2218 ± 132* 2021 ± 121
HW/BW (mg/g) 2.91 ± 0.27 2.94 ± 0.35 3.22 ± 0.37 3.13 ± 0.40
Sum of WAT mass (g) 28.5 ± 3.1 27.7 ± 3.3 63.6 ± 5.9* 57.9 ± 4.2
  1. Sum of WAT mass includes inguinal, retroperitoneal, epididymal and mesenteric WAT mass. Values are mean ± SE. n = 10 for each group
  2. OH obesity-related hypertension rats induced by high fat diet, BW body weight, HW heart weight, WAT white adipose tissue
  3. * p < 0.05 versus Control; #p < 0.05 versus OH