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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Kinetics of MSC-based enzyme therapy for immunoregulation

Fig. 3

Michaelis Menton modeling of MSC hydrolysis. ae Rates for each population size were determined as a function of dose by finding the slopes of hydrolysis against time graphs. Using non-linear regression fitting, rates as a function of dose were fit to first-order enzyme kinetic equations, which show that Vmax and Km increase as population size increases. For all models, R2 > 0.95 and n = 3. f There is a linear relationship between Vmax and normalized cell population, of which the slope determines the maximum hydrolysis rate per cell

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