Skip to main content

Table 1 Basal expression of chemokine receptors by melanoma cells

From: Tumor-derived exosomes promote the in vitro osteotropism of melanoma cells by activating the SDF-1/CXCR4/CXCR7 axis

Cell line

CXCR4

CXCR7

Membrane

Intracellular

Membrane

Intracellular

%

MFI

%

MFI

%

MFI

%

MFI

LCP

6.5 ± 2.1

6.7 ± 1.4

88.0 ± 4.6

5.1 ± 2.0

17.5±3.2

8.6 ± 1.4

94.7±4.9

5.4 ± 1.7

SK-Mel28

10.1 ± 2.7

5.0 ± 0.9

84.6 ± 3.8

4.3 ± 1.7

10.4 ± 2.7

7.5 ± 0.7

82.5 ± 3.7

4.3 ± 1.1

WM-266

8.4 ± 1.8

5.6 ± 1.2

87.1 ± 4.2

4.5 ± 1.3

9.4 ± 2.5

6.8 ± 0.9

79.5 ± 4.2

4.1 ± 0.8

 

p 0.2

p 0.7

p 0.15

p 0.9

p 0.07

p 0.8

p 0.02

p 0.7

  1. Values are percentage of fluorescent cells and relative mean fluorescence intensity (MFI)
  2. Membrane and intracellular levels of CXCR7 by LCP (bolditalics) were higher as compared to SK-Mel28 and WM-266 cells
  3. Italic values refer to the p values calculated with “One-way ANOVA test” for the differences observed between cells in their CXCR4/CXCR7 basal levels