Skip to main content

Table 2 Echocardiographic parameters of the animals

From: Advantages of prophylactic versus conventionally scheduled heart failure therapy in an experimental model of doxorubicin-induced cardiomyopathy

  CON (n = 6–7) D-CON (n = 7–11) PRE (n = 6–8) POST (n = 4–7)
Day 0 Day 51 Day 80 Day 0 Day 51 Day 80 Day 0 Day 51 Day 80 Day 0 Day 51 Day 80
EF (%) 85.33 ± 1.34 81.62 ± 2.55+ 83.95 ± 1.34+^ 81.17 ± 1.50 74.1 ± 2.28*§# 66.35 ± 3.58*§#† 83.71 ± 2.11 82.5 ± 1.62+ 81.25 ± 1.96+^ 85.52 ± 2.4 79.33 ± 2.46 71.95 ± 3.4*§
LVEDd (mm) 5.52 ± 0.2 5.66 ± 0.23 6.39 ± 0.27# 5.26 ± 0.21 5.76 ± 0.3 5.89 ± 0.28# 5.61 ± 0.12 6.07 ± 0.19 5.88 ± 0.28 5.27 ± 0.19 5.98 ± 0.23# 5.89 ± 0.15
LVESd (mm) 2.61 ± 0.27 3.08 ± 0.22 3.34 ± 0.21# 2.92 ± 0.19 3.61 ± 0.28# 3.98 ± 0.28# 2.92 ± 0.15 3.27 ± 0.17 3.21 ± 0.19 2.64 ± 0.2 3.26 ± 0.22 3.73 ± 0.23#
PWd (mm) 0.86 ± 0.05 0.79 ± 0.03 0.94 ± 0.03^ 0.8 ± 0.02 0.91 ± 0.03*# 0.91 ± 0.03^# 0.85 ± 0.02 0.9 ± 0.02* 0.96 ± 0.05 0.87 ± 0.03 0.86 ± 0.02 1.07 ± 0.05*+#†
PWs (mm) 1.12 ± 0.05+ 0.94 ± 0.04§# 1.25 ± 0.07+† 0.95 ± 0.03* 0.99 ± 0.03 1 ± 0.05*^ 0.99 ± 0.04 1.09 ± 0.04* 1.14 ± 0.05# 1.02 ± 0.02 1.02 ± 0.03 1.28 ± 0.06+#†
IVSd (mm) 0.99 ± 0.07 0.99 ± 0.07# 1.44 ± 0.13# 1.02 ± 0.06 1.08 ± 0.09 1.28 ± 0.08§# 1.02 ± 0.07 1.1 ± 0.07 1.61 ± 0.13+#† 0.96 ± 0.04 1.02 ± 0.05 1.46 ± 0.07#†
IVSs (mm) 1.13 ± 0.05 1.25 ± 0.08 1.74 ± 0.17+# 1.14 ± 0.07 1.23 ± 0.09 1.33 ± 0.08*# 1.12 ± 0.07 1.28 ± 0.06^ 1.72 ± 0.2# 1.07 ± 0.05 1.12 ± 0.03§ 1.75 ± 0.19#†
IVCT (ms) 18.46 ± 1.29 17.81 ± 1.34 15.51 ± 0.73+# 18.64 ± 2.7 19.09 ± 1.59 23.66 ± 3.23* 19.46 ± 1.31 17.92 ± 1.24 16.42 ± 1.86 17.76 ± 0.75 19.43 ± 1.2 17.95 ± 0.99
IVRT (ms) 26.24 ± 0.78 27.81 ± 1.05+ 27.81 ± 1.44^ 28.24 ± 1.48 32.45 ± 1.56* 32.1 ± 2.37 25.5 ± 0.66 29.42 ± 1.68 32.29 ± 2.42# 25.86 ± 1.03 29.19 ± 1.83 34.14 ± 1.28*#†
DecT (ms) 41.79 ± 4.25 25.86 ± 4.37 50.33 ± 1.62+ 40.33 ± 3.36 44.62 ± 2.3 42.71 ± 2.73* 41.79 ± 2.73 51 ± 1.95# 51.96 ± 3.96# 43.62 ± 2.33 43.62 ± 4.5 49.38 ± 4.81
ET (ms) 62.9 ± 1.58 59.62 ± 1.95§^ 62.86 ± 1.68+§^ 60.42 ± 1.97 68.04 ± 3.32# 69.46 ± 2.19*§^# 60.96 ± 1.35 70.25 ± 1.38*# 77.29 ± 2.67*+#† 60.48 ± 1.67 68.38 ± 2.45*# 78.57 ± 3.39*+#†
E (cm/s) 66.78 ± 3.14 58.33 ± 4.55 59 ± 2.83 58.79 ± 4.85 55.58 ± 3.05§ 59.67 ± 2.41 67.25 ± 3.43 70.54 ± 4.93+ 60 ± 3.43 65.76 ± 4.49 67.1 ± 3.7 59.71 ± 5.42
A (cm/s) 50.46 ± 3.16 39.57 ± 4.97 34.52 ± 2.23^# 42.67 ± 4.67 38.92 ± 3.14 36.71 ± 2.68^ 50.25 ± 3.71 45.08 ± 3.48 36.63 ± 2.7# 47.71 ± 4.47 38.67 ± 4 26.05 ± 2.84*+#†
e’ (cm/s) 4.63 ± 0.76 3.71 ± 0.29 4.43 ± 0.29§ 3.96 ± 0.24 4.04 ± 0.3 4.33 ± 0.38 4.12 ± 0.3 3.83 ± 0.34 3.54 ± 0.26* 3.9 ± 0.24 4.29 ± 0.43 3.9 ± 0.35
a’ (cm/s) 6.1 ± 0.48 5.57 ± 0.54+ 3.19 ± 0.18+§#† 5.38 ± 0.4 4.12 ± 0.25*# 5.04 ± 0.84*^ 6.08 ± 0.55 4.38 ± 0.38# 3.92 ± 0.22*^# 6.1 ± 0.61 4.67 ± 0.47 3.24 ± 0.27+§#
s’ (mm/s) 30.49 ± 2.38 33.48 ± 1.94§^ 31.33 ± 2.7§^ 37.08 ± 5.44 33.58 ± 2.2§^ 30 ± 1.36§^ 31.25 ± 2.78 27.25 ± 1.4*+ 22.42 ± 1.4*+#† 30 ± 2.78 25.48 ± 0.69*+ 21.62 ± 0.83*+#†
E/e’ 16.15 ± 1.96 16.13 ± 1.56 13.84 ± 1.46 15.45 ± 1.93 14.05 ± 0.86 14.56 ± 1.49 17 ± 1.67 19.68 ± 2.4 17.5 ± 1.67 17.07 ± 1.19 16.62 ± 2.02 15.98 ± 1.83
Septal strain (%) –20.17 ± 4.61 –24.04 ± 1.45 –16.83 ± 2.18 –18.32 ± 2.81 –20.15 ± 1.57 –15.64 ± 1.83 –21.53 ± 2.6 –20.65 ± 1.4 –17.38 ± 2.67 –15.37 ± 4.82 –14.73 ± 3.7 –11.36 ± 3.37
Strain rate S (1/s) –5.06 ± 0.36 –4.9 ± 1.12 –5.03 ± 0.9 –4.8 ± 0.63 –5.35 ± 0.69 –3.49 ± 0.44§ –5.32 ± 0.68 –5.04 ± 0.27 –4.13 ± 0.25+ –4.5 ± 0.52 –5.09 ± 0.56 –3.25 ± 0.78
Strain rate E (1/s) 4.82 ± 1.1 5.12 ± 0.58 4.12 ± 0.61^ 5.16 ± 0.44 4.58 ± 0.72 2.33 ± 0.73# 6.25 ± 0.77 4.2 ± 0.53 2.87 ± 1.16 4.9 ± 0.99 4.56 ± 0.3 2.0 ± 0.3*
Tei-index 0.72 ± 0.03 0.78 ± 0.05§ 0.69 ± 0.05 0.8 ± 0.09 0.82 ± 0.03§^ 0.82 ± 0.06§^ 0.73 ± 0.03 0.67 ± 0.03*+ 0.66 ± 0.05+ 0.71 ± 0.03 0.71 ± 0.04+ 0.65 ± 0.03+
  1. A mitral A wave, a′ late diastolic velocity of the mitral anulus, DecT deceleration time, E mitral E wave, e′ early diastolic velocity of the mitral anulus, EF ejection fraction, ET ejection time, IVCT isovolumetric contraction time, IVRT isovolumetric relaxation time, IVSd diastolic thickness of the interventricular septum, IVSs systolic thickness of the interventricular septum, LVEDd end-diastolic diameter of the left ventricle, LVESd end-systolic diameter of the left ventricle, PWd diastolic thickness of the posterior wall, PWs systolic thickness of the posterior wall, s′ systolic velocity of the mitral anulus, Strain rate E strain rate measured at the time of the E wave (diastolic), Strain rate S strain rate measured at the time of the s wave (systolic), Tei-index myocardial performance index [(IVCT + IVRT)/ET], n number of animals per group (3 measurements per animal, except for single strain measurements)
  2. * p ≤ 0.05 vs. CON; + p ≤ 0.05 vs. D-CON; § p ≤ 0.05 vs. PRE; ^ p ≤ 0.05 vs. POST; # p ≤ 0.05 vs. day 0;  p ≤ 0.05 vs. day 51