CON (n = 6–7) | D-CON (n = 7–11) | PRE (n = 6–8) | POST (n = 4–7) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Day 0 | Day 51 | Day 80 | Day 0 | Day 51 | Day 80 | Day 0 | Day 51 | Day 80 | Day 0 | Day 51 | Day 80 | |
EF (%) | 85.33 ± 1.34 | 81.62 ± 2.55+ | 83.95 ± 1.34+^ | 81.17 ± 1.50 | 74.1 ± 2.28*§# | 66.35 ± 3.58*§#† | 83.71 ± 2.11 | 82.5 ± 1.62+ | 81.25 ± 1.96+^ | 85.52 ± 2.4 | 79.33 ± 2.46 | 71.95 ± 3.4*§ |
LVEDd (mm) | 5.52 ± 0.2 | 5.66 ± 0.23 | 6.39 ± 0.27# | 5.26 ± 0.21 | 5.76 ± 0.3 | 5.89 ± 0.28# | 5.61 ± 0.12 | 6.07 ± 0.19 | 5.88 ± 0.28 | 5.27 ± 0.19 | 5.98 ± 0.23# | 5.89 ± 0.15 |
LVESd (mm) | 2.61 ± 0.27 | 3.08 ± 0.22 | 3.34 ± 0.21# | 2.92 ± 0.19 | 3.61 ± 0.28# | 3.98 ± 0.28# | 2.92 ± 0.15 | 3.27 ± 0.17 | 3.21 ± 0.19 | 2.64 ± 0.2 | 3.26 ± 0.22 | 3.73 ± 0.23# |
PWd (mm) | 0.86 ± 0.05 | 0.79 ± 0.03+§ | 0.94 ± 0.03^† | 0.8 ± 0.02 | 0.91 ± 0.03*# | 0.91 ± 0.03^# | 0.85 ± 0.02 | 0.9 ± 0.02* | 0.96 ± 0.05 | 0.87 ± 0.03 | 0.86 ± 0.02 | 1.07 ± 0.05*+#† |
PWs (mm) | 1.12 ± 0.05+ | 0.94 ± 0.04§# | 1.25 ± 0.07+† | 0.95 ± 0.03* | 0.99 ± 0.03 | 1 ± 0.05*^ | 0.99 ± 0.04 | 1.09 ± 0.04* | 1.14 ± 0.05# | 1.02 ± 0.02 | 1.02 ± 0.03 | 1.28 ± 0.06+#† |
IVSd (mm) | 0.99 ± 0.07 | 0.99 ± 0.07# | 1.44 ± 0.13# | 1.02 ± 0.06 | 1.08 ± 0.09 | 1.28 ± 0.08§# | 1.02 ± 0.07 | 1.1 ± 0.07 | 1.61 ± 0.13+#† | 0.96 ± 0.04 | 1.02 ± 0.05 | 1.46 ± 0.07#† |
IVSs (mm) | 1.13 ± 0.05 | 1.25 ± 0.08 | 1.74 ± 0.17+# | 1.14 ± 0.07 | 1.23 ± 0.09 | 1.33 ± 0.08*# | 1.12 ± 0.07 | 1.28 ± 0.06^ | 1.72 ± 0.2# | 1.07 ± 0.05 | 1.12 ± 0.03§ | 1.75 ± 0.19#† |
IVCT (ms) | 18.46 ± 1.29 | 17.81 ± 1.34 | 15.51 ± 0.73+# | 18.64 ± 2.7 | 19.09 ± 1.59 | 23.66 ± 3.23* | 19.46 ± 1.31 | 17.92 ± 1.24 | 16.42 ± 1.86 | 17.76 ± 0.75 | 19.43 ± 1.2 | 17.95 ± 0.99 |
IVRT (ms) | 26.24 ± 0.78 | 27.81 ± 1.05+ | 27.81 ± 1.44^ | 28.24 ± 1.48 | 32.45 ± 1.56* | 32.1 ± 2.37 | 25.5 ± 0.66 | 29.42 ± 1.68 | 32.29 ± 2.42# | 25.86 ± 1.03 | 29.19 ± 1.83 | 34.14 ± 1.28*#† |
DecT (ms) | 41.79 ± 4.25 | 25.86 ± 4.37 | 50.33 ± 1.62+ | 40.33 ± 3.36 | 44.62 ± 2.3 | 42.71 ± 2.73* | 41.79 ± 2.73 | 51 ± 1.95# | 51.96 ± 3.96# | 43.62 ± 2.33 | 43.62 ± 4.5 | 49.38 ± 4.81 |
ET (ms) | 62.9 ± 1.58 | 59.62 ± 1.95§^ | 62.86 ± 1.68+§^ | 60.42 ± 1.97 | 68.04 ± 3.32# | 69.46 ± 2.19*§^# | 60.96 ± 1.35 | 70.25 ± 1.38*# | 77.29 ± 2.67*+#† | 60.48 ± 1.67 | 68.38 ± 2.45*# | 78.57 ± 3.39*+#† |
E (cm/s) | 66.78 ± 3.14 | 58.33 ± 4.55 | 59 ± 2.83 | 58.79 ± 4.85 | 55.58 ± 3.05§ | 59.67 ± 2.41 | 67.25 ± 3.43 | 70.54 ± 4.93+ | 60 ± 3.43 | 65.76 ± 4.49 | 67.1 ± 3.7 | 59.71 ± 5.42 |
A (cm/s) | 50.46 ± 3.16 | 39.57 ± 4.97 | 34.52 ± 2.23^# | 42.67 ± 4.67 | 38.92 ± 3.14 | 36.71 ± 2.68^ | 50.25 ± 3.71 | 45.08 ± 3.48 | 36.63 ± 2.7# | 47.71 ± 4.47 | 38.67 ± 4 | 26.05 ± 2.84*+#† |
e’ (cm/s) | 4.63 ± 0.76 | 3.71 ± 0.29 | 4.43 ± 0.29§ | 3.96 ± 0.24 | 4.04 ± 0.3 | 4.33 ± 0.38 | 4.12 ± 0.3 | 3.83 ± 0.34 | 3.54 ± 0.26* | 3.9 ± 0.24 | 4.29 ± 0.43 | 3.9 ± 0.35 |
a’ (cm/s) | 6.1 ± 0.48 | 5.57 ± 0.54+ | 3.19 ± 0.18+§#† | 5.38 ± 0.4 | 4.12 ± 0.25*# | 5.04 ± 0.84*^ | 6.08 ± 0.55 | 4.38 ± 0.38# | 3.92 ± 0.22*^# | 6.1 ± 0.61 | 4.67 ± 0.47 | 3.24 ± 0.27+§# |
s’ (mm/s) | 30.49 ± 2.38 | 33.48 ± 1.94§^ | 31.33 ± 2.7§^ | 37.08 ± 5.44 | 33.58 ± 2.2§^ | 30 ± 1.36§^ | 31.25 ± 2.78 | 27.25 ± 1.4*+ | 22.42 ± 1.4*+#† | 30 ± 2.78 | 25.48 ± 0.69*+ | 21.62 ± 0.83*+#† |
E/e’ | 16.15 ± 1.96 | 16.13 ± 1.56 | 13.84 ± 1.46 | 15.45 ± 1.93 | 14.05 ± 0.86 | 14.56 ± 1.49 | 17 ± 1.67 | 19.68 ± 2.4 | 17.5 ± 1.67 | 17.07 ± 1.19 | 16.62 ± 2.02 | 15.98 ± 1.83 |
Septal strain (%) | –20.17 ± 4.61 | –24.04 ± 1.45 | –16.83 ± 2.18 | –18.32 ± 2.81 | –20.15 ± 1.57 | –15.64 ± 1.83 | –21.53 ± 2.6 | –20.65 ± 1.4 | –17.38 ± 2.67 | –15.37 ± 4.82 | –14.73 ± 3.7 | –11.36 ± 3.37 |
Strain rate S (1/s) | –5.06 ± 0.36 | –4.9 ± 1.12 | –5.03 ± 0.9 | –4.8 ± 0.63 | –5.35 ± 0.69 | –3.49 ± 0.44§ | –5.32 ± 0.68 | –5.04 ± 0.27 | –4.13 ± 0.25+ | –4.5 ± 0.52 | –5.09 ± 0.56 | –3.25 ± 0.78 |
Strain rate E (1/s) | 4.82 ± 1.1 | 5.12 ± 0.58 | 4.12 ± 0.61^ | 5.16 ± 0.44 | 4.58 ± 0.72 | 2.33 ± 0.73# | 6.25 ± 0.77 | 4.2 ± 0.53 | 2.87 ± 1.16 | 4.9 ± 0.99 | 4.56 ± 0.3 | 2.0 ± 0.3* |
Tei-index | 0.72 ± 0.03 | 0.78 ± 0.05§ | 0.69 ± 0.05 | 0.8 ± 0.09 | 0.82 ± 0.03§^ | 0.82 ± 0.06§^ | 0.73 ± 0.03 | 0.67 ± 0.03*+ | 0.66 ± 0.05+ | 0.71 ± 0.03 | 0.71 ± 0.04+ | 0.65 ± 0.03+ |