Fig. 6

Force measurements in isolated cardiomyocytes. No significant change in the Ca²⁺-sensitivity (pCa₅₀, a, c), active (e) or passive force values (f) could be detected, but a significant decrease in the k_tr,max was observed in all DOX-exposed groups, which could not be prevented by any treatment applied (b, d). Illustration of an isolated cardiomyocyte. pCa₅₀ = Ca²⁺-sensitivity of isometric force production, k_tr,max = rate constant of force redevelopment. n number of animals per group (2–4 cardiomyocytes per animal); Statistics: Wilcoxon’s rank-sum test; numbers are p values; NS: non-significant