Table 3 References on translational success in general and in efficacy studies
From: Animal to human translation: a systematic scoping review of reported concordance rates
Study ID | Field of research | Summary of findings |
|---|---|---|
Briassoulis_2014 | Sepsis | Animal studies show clear protective effects of HSP72 in sepsis, human studies are inconclusive |
Brossi_2015 | Orthopedia | Equine studies on the efficacy of platelet rich plasma (k = 63) mostly show positive results, human studies (k = 60) have variable outcomes. Beneficial results are more frequent in studies with a high risk of bias |
Contopoulos-Ioannidis_2003 | Diverse | Out of 64 publications of animal studies in highly cited basic science journals, 16 interventions were tested in a published clinical trial, 12 of which had positive results |
Corpet_2005 | Oncology | Relative Risks after treatment were discordant for 2 out of 11 compounds between rats and humans, and mice and humans |
Faggion_2009A | Dentistry | pocket depth reduction and attachment level gain were similar for animals and humans |
Hackam_2006 | Diverse | Successful translation is not predicted by study methodology, but it is predicted by the presence of dose–response gradients in animals |
Johnson_2001 | Oncology | Xenograft models that were available at this stage could not reliably predict the clinical response |
Lindl_2005 | Diverse | The publications resulting from 51 animal ethics approvals were followed. 16 projects were relevant to humans and resulted in 63 publications that were cited 1183 times. 97 citations were clinically oriented, of which only 4 evidenced an animal-human correlation. The hypotheses verified in animals failed in every respect in humans |
Perel_2006 | Diverse | For 6 interventions, animal and clinical studies were concordant for 3 and discordant for the other 3 |
Steinberg_1987 | Pancreatitis | With the same 5 interventions, 81% of animal studies had a positive outcome, and only 7.7% of the human studies. |
Sultan_2017 | Cardiology | Most of the human data did not show any effect of cannabidiol, while the animal studies did |
Valles_2018 | Dentistry | Results from animal and human studies are concordant |
Voskoglou-Nomikos_2003 | Cancer | None of the primary analyses showed a significant correlation |
Whiteside_2008 | Pain | For effective pain treatments, the correlation between human and rat effective doses is good |
Yardley_2016 | Alcohol abuse | Out of 49 animal studies (on 8 drugs), 45 showed positive results. Out of 76 human studies, 56 showed positive results. |
Yen_2014 | Dentistry | Animal models and human results showed similar bone filling ratios |