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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Identification of novel pathogenic MSH2 mutation and new DNA repair genes variants: investigation of a Tunisian Lynch syndrome family with discordant twins

Fig. 2

Representative MMR immunohistochemical expression patterns. Left panel: (a, b, c and d) are IHC pictures of a sporadic CRC sample with proficient MMR (pMMR). The pMMR sample staining shows strong nuclear expression in both tumor (red arrow) and adjacent stromal cells (internal control, green arrow) for the four used antibodies anti-PMS2 (a), anti-MLH1 (b), anti-MSH2 (c) and anti-MSH6 (d). Right panel: (e, f, g and h) are IHC pictures of the index case CRC with deficient MMR (dMMR). The dMMR proband staining showed: a loss of nuclear MSH2 expression in normal stromal and cancer cells (g) confirming the MMR deficiency, a nuclear incomplete staining for MLH1 (f) and a cytoplasmic staining for PMS2 (e) and MSH6 (h) (yellow arrow). Original magnifications (40x)

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Journal of Translational Medicine

ISSN: 1479-5876

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