EV-associated miRNAs from peritoneal lavage as potential diagnostic biomarkers in colorectal cancer

Roman-Canal, Berta; Tarragona, Jordi; Moiola, Cristian Pablo; Gatius, Sònia; Bonnin, Sarah; Ruiz-Miró, Maria; Sierra, José Enrique; Rufas, Maria; González, Esperanza; Porcel, José M.; Gil-Moreno, Antonio; Falcón-Pérez, Juan M.; Ponomarenko, Julia; Matias-Guiu, Xavier; Colas, Eva

doi:10.1186/s12967-019-1954-8

Journal of Translational Medicine

Table 2 miRNA transcripts displaying a significant differential expression in patients with CRC compared to control patients

From: EV-associated miRNAs from peritoneal lavage as potential diagnostic biomarkers in colorectal cancer

miRNA	LogFC	p-value	Adj. p-value	AUC	AUC 95% CI_lower	AUC 95% CI_upper	Accuracy	Sensitivity	Specificity
hsa-miR-199b-5p_478486_mir	− 12.82	2.59E−08	9.85E−07	1	1	1	0.967	0.968	0.964
hsa-miR-150-5p_477918_mir	2.58	7.10E−05	3.41E−04	0.978	0.959	0.996	0.919	0.936	0.899
hsa-miR-29c-5p_478005_mir	− 2.93	2.78E−08	9.85E−07	0.973	0.954	0.991	0.943	0.943	0.944
hsa-miR-218-5p_477977_mir	− 8.16	6.51E−07	8.25E−06	0.97	0.945	0.995	0.913	0.905	0.921
hsa-miR-99a-3p_479224_mir	− 4.89	1.51E−08	8.95E−07	0.97	0.95	0.99	0.94	0.976	0.9
hsa-miR-383-5p_478079_mir	− 8.33	3.55E−15	1.26E−12	0.968	0.952	0.985	0.939	0.94	0.938
hsa-miR-199a-3p_477961_mir	− 6.16	2.84E−09	2.65E−07	0.968	0.942	0.994	0.905	0.92	0.887
hsa-miR-193a-5p_477954_mir	− 3.62	1.32E−06	1.56E−05	0.962	0.932	0.991	0.873	0.852	0.897
hsa-miR-10b-5p_478494_mir	− 2.79	2.58E−07	4.17E−06	0.957	0.93	0.983	0.871	0.875	0.866
hsa-miR-181c-5p_477934_mir	− 3.52	1.23E−05	8.74E−05	0.952	0.929	0.974	0.833	0.859	0.803
hsa-miR-708-5p_478197_mir	− 6.45	9.72E−08	2.29E−06	0.946	0.917	0.975	0.877	0.834	0.926
hsa-miR-125b-5p_477885_mir	− 2.35	9.27E−07	1.13E−05	0.946	0.918	0.974	0.885	0.884	0.885
hsa-miR-140-5p_477909_mir	− 5.82	4.59E−05	2.39E−04	0.943	0.919	0.968	0.817	0.825	0.807
hsa-miR-451a_478107_mir	− 8.35	1.34E−07	2.64E−06	0.942	0.913	0.972	0.843	0.881	0.8
hsa-miR-148b-3p_477824_mir	− 3.05	1.42E−07	2.66E−06	0.942	0.916	0.968	0.834	0.853	0.813
hsa-miR-130a-3p_477851_mir	− 2.62	1.85E−06	2.00E−05	0.94	0.909	0.972	0.861	0.884	0.835
hsa-miR-214-3p_477974_mir	− 7.59	1.19E−07	2.49E−06	0.937	0.901	0.972	0.896	0.94	0.846
hsa-miR-10a-5p_479241_mir	− 2.19	1.44E−02	2.82E−02	0.937	0.906	0.969	0.897	0.904	0.889
hsa-miR-497-5p_478138_mir	− 3.68	2.13E−04	8.08E−04	0.936	0.911	0.961	0.814	0.829	0.797
hsa-miR-143-3p_477912_mir	− 3.15	1.58E−06	1.81E−05	0.936	0.906	0.965	0.86	0.868	0.85
hsa-miR-20a-5p_478586_mir	− 2.79	5.14E−08	1.30E−06	0.933	0.901	0.964	0.877	0.906	0.843
hsa-miR-29c-3p_479229_mir	− 3.55	2.14E−04	8.08E−04	0.931	0.897	0.965	0.86	0.84	0.883
hsa-miR-17-5p_478447_mir	− 3.68	4.83E−05	2.41E−04	0.93	0.893	0.966	0.874	0.898	0.847
hsa-miR-486-5p_478128_mir	− 11.10	2.21E−07	3.73E−06	0.929	0.899	0.958	0.853	0.818	0.893
hsa-miR-145-5p_477916_mir	− 3.07	6.47E−06	5.34E−05	0.929	0.899	0.958	0.877	0.901	0.851
hsa-miR-214-5p_478768_mir	− 8.13	2.33E−08	9.85E−07	0.923	0.885	0.96	0.877	0.906	0.844
hsa-miR-20b-5p_477804_mir	− 11.65	3.73E−09	2.65E−07	0.921	0.887	0.956	0.883	0.879	0.887
hsa-miR-551b-3p_478159_mir	− 9.71	2.07E−10	3.68E−08	0.919	0.885	0.953	0.852	0.906	0.79
hsa-miR-107_478254_mir	− 4.70	1.35E−03	3.73E−03	0.917	0.883	0.951	0.919	0.938	0.898
hsa-miR-202-5p_478755_mir	− 7.19	5.11E−08	1.30E−06	0.915	0.876	0.954	0.855	0.867	0.842
hsa-miR-93-5p_478210_mir	− 2.84	3.88E−04	1.30E−03	0.915	0.875	0.954	0.86	0.872	0.847
hsa-miR-483-3p_478122_mir	− 7.01	3.69E−09	2.65E−07	0.913	0.877	0.949	0.837	0.884	0.784
hsa-miR-652-3p_478189_mir	− 2.05	2.63E−05	1.70E−04	0.913	0.882	0.945	0.825	0.831	0.818
hsa-miR-29b-3p_478369_mir	− 3.59	3.71E−06	3.47E−05	0.911	0.877	0.945	0.836	0.834	0.838
hsa-miR-328-3p_478028_mir	− 5.03	2.86E−04	1.01E−03	0.908	0.874	0.941	0.819	0.798	0.842
hsa-miR-25-3p_477994_mir	− 2.37	3.44E−05	1.99E−04	0.908	0.87	0.946	0.865	0.899	0.827
hsa-miR-26a-5p_477995_mir	− 2.30	1.99E−05	1.38E−04	0.904	0.872	0.937	0.796	0.799	0.791
hsa-miR-296-5p_477836_mir	− 6.51	3.42E−05	1.99E−04	0.903	0.865	0.941	0.878	0.796	0.973
hsa-miR-144-3p_477913_mir	− 5.05	3.53E−05	1.99E−04	0.903	0.867	0.938	0.827	0.85	0.801
hsa-miR-769-5p_478203_mir	− 3.98	3.53E−05	1.99E−04	0.903	0.864	0.942	0.899	0.901	0.896
hsa-miR-181a-5p_477857_mir	− 2.13	5.21E−06	4.52E−05	0.902	0.865	0.939	0.843	0.895	0.783
hsa-miR-29a-3p_478587_mir	− 3.12	1.16E−03	3.38E−03	0.901	0.86	0.942	0.878	0.854	0.905
hsa-miR-152-3p_477921_mir	− 3.98	2.17E−05	1.48E−04	0.9	0.866	0.934	0.804	0.791	0.819
hsa-miR-125b-1-3p_478665_mir	− 9.13	1.93E−07	3.42E−06	0.895	0.86	0.931	0.86	0.868	0.851
hsa-miR-30a-3p_478273_mir	− 1.66	9.38E−05	4.27E−04	0.891	0.854	0.928	0.812	0.793	0.834
hsa-miR-449b-5p_479528_mir	− 10.10	2.30E−08	9.85E−07	0.889	0.846	0.932	0.88	0.908	0.847
hsa-miR-219a-5p_477980_mir	− 6.58	5.10E−07	7.54E−06	0.889	0.852	0.926	0.84	0.854	0.824
hsa-miR-125a-5p_477884_mir	− 1.40	1.48E−03	4.02E−03	0.888	0.846	0.93	0.827	0.84	0.813
hsa-miR-374b-3p_479421_mir	− 4.64	2.15E−06	2.24E−05	0.887	0.845	0.929	0.8	0.791	0.81
hsa-miR-101-3p_477863_mir	− 4.19	6.98E−05	3.39E−04	0.886	0.845	0.927	0.832	0.896	0.759
hsa-miR-452-5p_478109_mir	− 3.88	2.89E−05	1.80E−04	0.886	0.852	0.92	0.751	0.737	0.766
hsa-miR-193a-3p_478306_mir	− 2.46	2.37E−03	5.97E−03	0.884	0.841	0.928	0.869	0.899	0.835
hsa-miR-148a-3p_477814_mir	− 1.48	1.24E−03	3.52E−03	0.884	0.845	0.923	0.822	0.818	0.826
hsa-miR-133a-3p_478511_mir	− 6.89	1.67E−04	6.73E−04	0.883	0.843	0.922	0.827	0.853	0.797
hsa-miR-675-5p_478196_mir	− 4.22	5.46E−06	4.61E−05	0.883	0.845	0.92	0.766	0.721	0.817
hsa-miR-34a-5p_478048_mir	− 2.04	3.41E−05	1.99E−04	0.882	0.841	0.922	0.823	0.801	0.848
hsa-miR-582-5p_478166_mir	− 8.33	3.37E−07	5.20E−06	0.881	0.842	0.92	0.84	0.767	0.923
hsa-miR-2110_477971_mir	− 4.46	2.45E−06	2.48E−05	0.879	0.837	0.92	0.782	0.794	0.769
hsa-miR-185-5p_477939_mir	− 2.69	1.09E−02	2.18E−02	0.879	0.836	0.921	0.828	0.872	0.777
hsa-miR-144-5p_477914_mir	− 11.46	4.47E−08	1.30E−06	0.877	0.833	0.921	0.873	0.944	0.791
hsa-miR-199a-5p_478231_mir	− 7.83	1.24E−04	5.31E−04	0.877	0.831	0.923	0.772	0.712	0.84
hsa-miR-361-5p_478056_mir	− 1.48	9.56E−04	2.83E−03	0.877	0.837	0.918	0.821	0.86	0.778
hsa-miR-195-5p_477957_mir	− 2.80	2.19E−04	8.17E−04	0.875	0.832	0.919	0.835	0.822	0.849
hsa-miR-136-5p_478307_mir	− 8.01	5.88E−07	8.03E−06	0.873	0.834	0.913	0.828	0.821	0.836
hsa-miR-548d-5p_480870_mir	− 3.80	3.79E−03	8.96E−03	0.873	0.827	0.919	0.755	0.65	0.875
hsa-miR-30b-5p_478007_mir	− 2.55	2.64E−03	6.47E−03	0.873	0.829	0.916	0.774	0.795	0.751
hsa-miR-363-3p_478060_mir	− 8.98	3.58E−05	1.99E−04	0.869	0.825	0.914	0.782	0.776	0.789
hsa-miR-27b-3p_478270_mir	− 2.46	2.87E−02	4.90E−02	0.868	0.828	0.908	0.76	0.815	0.698
hsa-miR-24-3p_477992_mir	− 2.06	4.68E−05	2.40E−04	0.868	0.823	0.913	0.859	0.9	0.813
hsa-miR-499a-5p_478139_mir	− 4.05	4.42E−05	2.34E−04	0.864	0.821	0.908	0.851	0.875	0.824
hsa-miR-15a-5p_477858_mir	− 1.96	3.80E−04	1.28E−03	0.863	0.823	0.903	0.77	0.781	0.758
hsa-miR-31-3p_478012_mir	− 5.27	2.92E−04	1.02E−03	0.86	0.817	0.904	0.799	0.766	0.836
hsa-miR-18a-3p_477944_mir	− 4.70	5.55E−05	2.74E−04	0.859	0.817	0.901	0.761	0.747	0.777
hsa-miR-92a-3p_477827_mir	− 1.48	5.48E−04	1.74E−03	0.859	0.811	0.907	0.813	0.822	0.804
hsa-miR-130b-3p_477840_mir	− 5.57	3.72E−04	1.27E−03	0.858	0.815	0.901	0.748	0.644	0.866
hsa-let-7b-5p_478576_mir	− 1.57	5.76E−04	1.81E−03	0.858	0.814	0.902	0.76	0.758	0.761
hsa-miR-30e-3p_478388_mir	− 4.70	5.51E−03	1.22E−02	0.854	0.81	0.899	0.753	0.628	0.897
hsa-miR-23b-5p_477991_mir	− 3.62	3.36E−05	1.99E−04	0.853	0.81	0.896	0.756	0.758	0.754
hsa-miR-29b-2-5p_478003_mir	− 4.33	2.79E−06	2.75E−05	0.85	0.806	0.894	0.797	0.806	0.786
hsa-miR-30e-5p_479235_mir	− 8.36	6.16E−04	1.92E−03	0.849	0.802	0.896	0.709	0.638	0.791
hsa-miR-200c-3p_478351_mir	− 7.14	2.32E−05	1.53E−04	0.848	0.802	0.894	0.802	0.721	0.894
hsa-miR-1180-3p_477869_mir	− 3.91	4.43E−05	2.34E−04	0.847	0.798	0.896	0.806	0.754	0.866
hsa-miR-190a-5p_478358_mir	− 1.89	1.87E−02	3.48E−02	0.847	0.801	0.892	0.829	0.814	0.847
hsa-miR-151b_477811_mir	− 9.82	2.25E−04	8.31E−04	0.846	0.801	0.892	0.761	0.733	0.792
hsa-miR-505-5p_478957_mir	− 5.86	4.24E−05	2.32E−04	0.846	0.801	0.891	0.796	0.805	0.786
hsa-miR-196b-5p_478585_mir	− 6.46	1.86E−06	2.00E−05	0.845	0.795	0.894	0.767	0.67	0.879
hsa-miR-324-5p_478024_mir	− 1.51	8.13E−03	1.65E−02	0.843	0.797	0.889	0.777	0.754	0.802
hsa-miR-224-5p_477986_mir	− 2.72	1.58E−04	6.45E−04	0.842	0.8	0.883	0.746	0.695	0.804
hsa-miR-139-5p_478312_mir	− 5.12	2.43E−04	8.80E−04	0.839	0.794	0.885	0.727	0.725	0.729
hsa-miR-545-5p_479003_mir	− 5.30	8.42E−06	6.79E−05	0.838	0.79	0.886	0.79	0.79	0.79
hsa-miR-222-3p_477982_mir	− 2.08	7.82E−04	2.37E−03	0.838	0.791	0.884	0.728	0.762	0.689
hsa-miR-340-5p_478042_mir	− 9.05	9.31E−06	7.18E−05	0.836	0.79	0.882	0.803	0.817	0.786
hsa-miR-504-5p_478144_mir	− 3.54	1.86E−04	7.18E−04	0.836	0.787	0.886	0.778	0.729	0.833
hsa-miR-106a-5p_478225_mir	− 10.76	4.30E−08	1.30E−06	0.834	0.784	0.883	0.816	0.924	0.693
hsa-miR-1271-5p_478674_mir	− 9.10	3.87E−06	3.52E−05	0.834	0.785	0.883	0.823	0.9	0.734
hsa-miR-125b-2-3p_478666_mir	− 6.80	9.11E−06	7.18E−05	0.834	0.782	0.886	0.804	0.866	0.735
hsa-miR-339-3p_478325_mir	− 3.60	6.56E−03	1.39E−02	0.834	0.782	0.886	0.778	0.692	0.876
hsa-miR-483-5p_478432_mir	− 6.45	5.42E−07	7.69E−06	0.832	0.783	0.882	0.785	0.871	0.687
hsa-miR-584-5p_478167_mir	− 10.36	6.40E−07	8.25E−06	0.831	0.781	0.882	0.803	0.906	0.685
hsa-miR-17-3p_477932_mir	− 8.43	2.22E−05	1.49E−04	0.831	0.779	0.883	0.805	0.861	0.741
hsa-miR-570-3p_479053_mir	− 4.46	1.11E−04	4.79E−04	0.831	0.785	0.876	0.766	0.697	0.844
hsa-miR-625-5p_479469_mir	− 10.93	4.36E−06	3.87E−05	0.83	0.781	0.88	0.806	0.865	0.738
hsa-miR-196a-5p_478230_mir	− 7.37	1.01E−05	7.64E−05	0.83	0.777	0.883	0.812	0.879	0.735
hsa-miR-7-1-3p_478198_mir	− 7.37	1.00E−04	4.52E−04	0.829	0.783	0.874	0.762	0.646	0.895
hsa-miR-450b-5p_478914_mir	− 9.65	1.03E−07	2.29E−06	0.828	0.775	0.88	0.803	0.906	0.685
hsa-miR-221-5p_478778_mir	− 5.01	3.08E−04	1.06E−03	0.827	0.779	0.875	0.745	0.64	0.865
hsa-miR-128-3p_477892_mir	− 1.32	5.21E−03	1.16E−02	0.823	0.772	0.874	0.743	0.741	0.746
hsa-miR-491-5p_478132_mir	− 3.50	1.88E−03	4.92E−03	0.822	0.774	0.87	0.743	0.703	0.79
hsa-miR-136-3p_477902_mir	− 7.94	2.78E−05	1.76E−04	0.821	0.771	0.871	0.786	0.855	0.707
hsa-miR-101-5p_478620_mir	− 7.44	1.09E−05	8.08E−05	0.819	0.766	0.873	0.812	0.877	0.738
hsa-miR-151a-3p_477919_mir	− 1.93	2.85E−04	1.01E−03	0.819	0.769	0.87	0.803	0.854	0.745
hsa-miR-28-3p_477999_mir	− 2.25	4.30E−03	1.00E−02	0.817	0.771	0.863	0.738	0.728	0.749
hsa-miR-489-3p_478130_mir	− 4.40	1.33E−04	5.62E−04	0.815	0.766	0.865	0.76	0.736	0.787
hsa-miR-106b-3p_477866_mir	− 2.41	6.48E−03	1.39E−02	0.815	0.765	0.866	0.72	0.693	0.751
hsa-miR-324-3p_478023_mir	− 7.87	2.85E−04	1.01E−03	0.814	0.766	0.861	0.761	0.686	0.847
hsa-miR-125a-3p_477883_mir	− 3.24	4.18E−04	1.39E−03	0.811	0.76	0.862	0.765	0.741	0.791
hsa-let-7i-3p_477862_mir	− 6.66	4.69E−04	1.54E−03	0.81	0.759	0.861	0.747	0.665	0.841
hsa-miR-33b-5p_478479_mir	− 5.49	2.06E−03	5.30E−03	0.81	0.758	0.862	0.704	0.626	0.793
hsa-miR-503-5p_478143_mir	− 2.80	6.04E−03	1.31E−02	0.81	0.757	0.863	0.762	0.726	0.805
hsa-miR-301a-3p_477815_mir	− 5.08	1.51E−03	4.05E−03	0.809	0.76	0.858	0.723	0.608	0.856
hsa-miR-330-3p_478030_mir	− 5.72	7.79E−04	2.37E−03	0.805	0.754	0.856	0.761	0.645	0.892
hsa-miR-425-5p_478094_mir	− 1.51	2.66E−02	4.63E−02	0.805	0.757	0.852	0.728	0.714	0.744
hsa-miR-16-2-3p_477931_mir	− 3.32	1.12E−02	2.22E−02	0.804	0.747	0.862	0.78	0.769	0.793
hsa-miR-548k_479374_mir	− 14.17	8.73E−03	1.76E−02	0.801	0.757	0.845	0.718	0.654	0.79
hsa-miR-429_477849_mir	− 2.00	1.76E−02	3.37E−02	0.801	0.747	0.854	0.768	0.807	0.723
hsa-miR-598-3p_478172_mir	− 1.51	4.51E−03	1.04E−02	0.8	0.754	0.847	0.696	0.726	0.661
hsa-miR-887-3p_479189_mir	− 5.41	1.42E−04	5.95E−04	0.799	0.748	0.85	0.737	0.632	0.858
hsa-miR-93-3p_478209_mir	− 4.60	2.28E−04	8.33E−04	0.798	0.745	0.852	0.749	0.702	0.801
hsa-miR-629-5p_478183_mir	− 6.16	1.75E−04	6.90E−04	0.796	0.746	0.846	0.753	0.678	0.839
hsa-miR-21-5p_477975_mir	1.32	7.91E−03	1.61E−02	0.796	0.751	0.842	0.683	0.688	0.677
hsa-miR-140-3p_477908_mir	− 3.42	6.10E−03	1.31E−02	0.793	0.743	0.843	0.734	0.752	0.713
hsa-miR-425-3p_478093_mir	− 5.28	9.90E−04	2.90E−03	0.792	0.74	0.844	0.728	0.588	0.888
hsa-miR-200a-5p_478752_mir	3.05	2.34E−02	4.15E−02	0.792	0.735	0.85	0.713	0.693	0.736
hsa-miR-590-3p_478168_mir	− 4.77	1.27E−03	3.56E−03	0.791	0.739	0.842	0.702	0.637	0.776
hsa-miR-30a-5p_479448_mir	− 8.52	7.71E−04	2.37E−03	0.789	0.738	0.841	0.734	0.726	0.744
hsa-let-7 g-3p_477850_mir	− 6.38	1.74E−04	6.90E−04	0.787	0.733	0.84	0.756	0.608	0.926
hsa-miR-542-3p_478153_mir	− 8.15	2.88E−06	2.76E−05	0.786	0.729	0.842	0.778	0.901	0.638
hsa-miR-31-5p_478015_mir	− 1.78	7.34E−03	1.51E−02	0.786	0.737	0.835	0.676	0.708	0.64
hsa-miR-379-5p_478077_mir	− 5.15	5.46E−04	1.74E−03	0.78	0.724	0.835	0.755	0.773	0.734
hsa-miR-194-5p_477956_mir	− 1.66	1.21E−03	3.48E−03	0.78	0.724	0.836	0.778	0.861	0.683
hsa-miR-34c-5p_478052_mir	− 2.51	4.47E−03	1.04E−02	0.779	0.726	0.832	0.685	0.639	0.738
hsa-miR-576-5p_478165_mir	− 6.85	8.70E−05	4.01E−04	0.778	0.721	0.836	0.774	0.853	0.684
hsa-miR-28-5p_478000_mir	− 5.87	1.45E−03	3.96E−03	0.778	0.726	0.829	0.731	0.64	0.835
hsa-miR-708-3p_479162_mir	− 2.77	2.27E−03	5.75E−03	0.772	0.715	0.828	0.738	0.74	0.736
hsa-miR-505-3p_478145_mir	− 2.12	3.62E−03	8.67E−03	0.771	0.718	0.824	0.758	0.737	0.781
hsa-miR-26b-5p_478418_mir	− 1.01	2.37E−02	4.19E−02	0.768	0.717	0.819	0.692	0.714	0.666
hsa-miR-365a-3p_478065_mir	− 4.75	2.67E−02	4.63E−02	0.767	0.713	0.822	0.661	0.495	0.85
hsa-miR-423-3p_478327_mir	− 1.63	1.58E−03	4.19E−03	0.765	0.716	0.815	0.65	0.687	0.607
hsa-miR-338-5p_478038_mir	− 3.61	2.40E−03	6.01E−03	0.761	0.703	0.819	0.704	0.719	0.687
hsa-miR-210-3p_477970_mir	− 1.17	1.67E−02	3.22E−02	0.761	0.708	0.815	0.672	0.698	0.643
hsa-miR-551a_478158_mir	− 5.58	1.97E−03	5.10E−03	0.76	0.699	0.822	0.741	0.69	0.8
hsa-miR-889-3p_478208_mir	− 8.68	1.14E−05	8.28E−05	0.759	0.698	0.82	0.789	0.922	0.637
hsa-miR-301b-3p_477825_mir	− 5.75	1.87E−02	3.48E−02	0.758	0.7	0.816	0.751	0.851	0.637
hsa-miR-590-5p_478367_mir	− 3.83	1.63E−02	3.15E−02	0.757	0.703	0.812	0.707	0.59	0.841
hsa-miR-548am-5p_480872_mir	− 3.25	1.13E−02	2.22E−02	0.757	0.703	0.81	0.663	0.526	0.82
hsa-miR-187-3p_477941_mir	− 4.47	6.97E−03	1.46E−02	0.754	0.701	0.807	0.704	0.644	0.772
hsa-miR-450a-5p_478106_mir	− 7.12	1.26E−03	3.56E−03	0.753	0.692	0.814	0.743	0.646	0.853
hsa-miR-376a-5p_478859_mir	− 5.94	1.04E−04	4.56E−04	0.75	0.688	0.811	0.738	0.832	0.631
hsa-miR-1296-5p_479451_mir	− 4.26	2.49E−03	6.17E−03	0.75	0.695	0.806	0.703	0.719	0.686
hsa-miR-181c-3p_477933_mir	− 3.64	9.29E−04	2.77E−03	0.748	0.685	0.811	0.715	0.805	0.613
hsa-miR-1247-5p_477882_mir	− 3.36	2.43E−02	4.26E−02	0.748	0.692	0.804	0.698	0.586	0.827
hsa-miR-34a-3p_478047_mir	− 2.32	1.77E−02	3.37E−02	0.748	0.694	0.803	0.658	0.727	0.579
hsa-miR-654-3p_479135_mir	− 7.56	4.77E−04	1.55E−03	0.74	0.681	0.799	0.76	0.692	0.839
hsa-miR-411-5p_478086_mir	− 5.12	7.16E−03	1.49E−02	0.738	0.68	0.796	0.715	0.647	0.793
hsa-miR-181d-5p_479517_mir	− 5.67	4.10E−03	9.63E−03	0.733	0.675	0.791	0.686	0.554	0.838
hsa-miR-200b-3p_477963_mir	− 3.43	7.26E−03	1.50E−02	0.733	0.674	0.792	0.683	0.609	0.767
hsa-miR-299-3p_478792_mir	− 6.51	4.73E−05	2.40E−04	0.732	0.67	0.794	0.748	0.893	0.582
hsa-miR-182-5p_477935_mir	− 8.68	8.37E−05	3.91E−04	0.73	0.666	0.795	0.753	0.9	0.585
hsa-miR-410-3p_478085_mir	− 5.65	1.22E−03	3.48E−03	0.728	0.67	0.787	0.753	0.771	0.733
hsa-miR-744-5p_478200_mir	− 3.55	1.81E−02	3.40E−02	0.725	0.67	0.781	0.657	0.637	0.68
hsa-miR-96-5p_478215_mir	− 6.84	1.03E−04	4.56E−04	0.724	0.658	0.79	0.744	0.886	0.583
hsa-miR-133b_480871_mir	− 3.18	1.98E−02	3.66E−02	0.724	0.664	0.783	0.686	0.651	0.726
hsa-miR-544a_478156_mir	− 5.67	1.37E−03	3.77E−03	0.719	0.66	0.779	0.756	0.81	0.694
hsa-miR-497-3p_478946_mir	− 6.92	1.44E−04	5.95E−04	0.718	0.652	0.784	0.753	0.899	0.585
hsa-miR-331-3p_478323_mir	− 5.93	3.27E−03	7.90E−03	0.715	0.656	0.774	0.761	0.775	0.744
hsa-let-7f-2-3p_477843_mir	− 3.26	1.19E−02	2.33E−02	0.715	0.655	0.776	0.682	0.567	0.814
hsa-miR-195-3p_478744_mir	− 4.54	6.67E−03	1.40E−02	0.712	0.652	0.773	0.717	0.712	0.723
hsa-miR-378a-5p_478076_mir	− 5.30	2.12E−03	5.41E−03	0.71	0.65	0.769	0.723	0.584	0.882
hsa-miR-1-3p_477820_mir	− 6.27	6.10E−03	1.31E−02	0.706	0.644	0.768	0.732	0.778	0.679
hsa-miR-615-3p_478175_mir	− 3.14	4.99E−03	1.13E−02	0.706	0.643	0.769	0.696	0.652	0.746
hsa-miR-545-3p_479002_mir	− 2.99	1.99E−02	3.66E−02	0.704	0.64	0.767	0.675	0.678	0.672
hsa-miR-548a-3p_478157_mir	− 3.75	4.83E−03	1.10E−02	0.703	0.641	0.765	0.716	0.572	0.881
hsa-miR-1248_478653_mir	− 2.64	1.08E−02	2.17E−02	0.702	0.642	0.763	0.707	0.764	0.643
hsa-miR-381-3p_477816_mir	− 5.10	5.97E−03	1.31E−02	0.701	0.639	0.763	0.734	0.727	0.742
hsa-miR-627-5p_478427_mir	− 4.94	5.01E−04	1.62E−03	0.701	0.632	0.77	0.735	0.863	0.589
hsa-miR-1301-3p_477897_mir	− 5.30	5.52E−03	1.22E−02	0.696	0.638	0.754	0.711	0.596	0.843
hsa-miR-486-3p_478422_mir	− 6.30	1.86E−04	7.18E−04	0.692	0.626	0.758	0.725	0.891	0.535
hsa-miR-200a-3p_478490_mir	− 4.37	1.79E−02	3.39E−02	0.691	0.626	0.756	0.719	0.792	0.635
hsa-miR-15a-3p_477928_mir	− 3.53	6.65E−03	1.40E−02	0.688	0.62	0.755	0.703	0.808	0.584
hsa-miR-548 g-3p_479020_mir	− 2.12	2.25E−02	4.04E−02	0.687	0.625	0.75	0.691	0.759	0.613
hsa-miR-432-5p_478101_mir	− 3.66	2.70E−02	4.65E−02	0.683	0.621	0.746	0.691	0.724	0.652
hsa-miR-15b-5p_478313_mir	− 6.53	2.89E−02	4.90E−02	0.682	0.619	0.745	0.666	0.692	0.637
hsa-miR-132-5p_478705_mir	− 6.01	3.23E−03	7.86E−03	0.68	0.614	0.745	0.734	0.867	0.582
hsa-let-7e-5p_478579_mir	− 5.40	2.04E−02	3.72E−02	0.679	0.614	0.744	0.655	0.556	0.769
hsa-miR-485-5p_478126_mir	− 2.09	2.46E−02	4.30E−02	0.678	0.613	0.743	0.688	0.734	0.634
hsa-miR-299-5p_478793_mir	− 5.05	8.70E−04	2.62E−03	0.672	0.603	0.741	0.702	0.858	0.524
hsa-miR-16-1-3p_478727_mir	− 4.44	1.55E−03	4.13E−03	0.669	0.603	0.735	0.699	0.841	0.537
hsa-miR-215-5p_478516_mir	− 7.23	8.19E−05	3.88E−04	0.668	0.601	0.735	0.718	0.896	0.514
hsa-miR-103a-2-5p_477864_mir	− 4.32	2.05E−02	3.73E−02	0.664	0.603	0.724	0.664	0.529	0.818
hsa-miR-29a-5p_478002_mir	− 6.48	2.54E−03	6.26E−03	0.643	0.568	0.717	0.723	0.896	0.524
hsa-miR-874-3p_478205_mir	− 2.80	2.77E−02	4.74E−02	0.638	0.575	0.701	0.617	0.524	0.722
hsa-miR-502-5p_478954_mir	− 4.03	2.18E−02	3.93E−02	0.637	0.573	0.701	0.662	0.53	0.813
hsa-miR-542-5p_478337_mir	− 5.28	3.71E−03	8.83E−03	0.633	0.564	0.702	0.68	0.855	0.481
hsa-miR-362-3p_478058_mir	− 5.81	1.73E−03	4.56E−03	0.632	0.564	0.701	0.69	0.879	0.475
hsa-miR-431-3p_478888_mir	− 4.55	4.63E−03	1.06E−02	0.624	0.552	0.696	0.678	0.853	0.478
hsa-miR-192-3p_478741_mir	− 4.08	5.15E−03	1.16E−02	0.61	0.535	0.685	0.674	0.85	0.474
hsa-miR-589-5p_479073_mir	− 2.81	2.28E−02	4.07E−02	0.582	0.512	0.652	0.633	0.795	0.448
hsa-miR-888-5p_479192_mir	− 3.79	2.06E−02	3.73E−02	0.559	0.489	0.63	0.656	0.861	0.422
hsa-miR-15b-3p_477929_mir	− 3.73	1.76E−02	3.37E−02	0.529	0.459	0.599	0.629	0.86	0.365
hsa-miR-651-5p_479131_mir	− 3.94	2.90E−02	4.90E−02	0.523	0.448	0.599	0.638	0.87	0.372

Log fold-change expression, p-value, adjusted p-value, AUC values, accuracy, sensitivity, specificity, and 95% of confidence intervals of the 210 dysregulated miRNAs
CI confidence of interval

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