Cytokine expression in Treponema pallidum infection

Table 1 Cytokine pairs classifying samples with incident syphilis

Cytokine 1	Cytokine 2	Chi squared p-value	Association	Covers	Left-no	Left-yes	Right-no	Right-yes	Rate-left	Rate-right	Rel risk	Odds-left	Odds-right	Odds ratio	95% CI
EOTAXIN	RANTES	0.006	Pos	26	2	9	12	3	0.82	0.20	4.09	4.50	0.25	18.00	2.47, 131.29
IL27	LEPTIN	0.009	Pos	25	2	11	9	3	0.85	0.25	3.38	5.50	0.33	16.50	2.25, 121.23
IL1RA	TRAIL	0.012	Pos	37	11	7	3	16	0.39	0.84	0.46	0.64	5.33	0.12	0.03, 0.57
IL1RA	MIG	0.028	Pos	35	11	6	4	14	0.35	0.78	0.45	0.55	3.50	0.16	0.04, 0.69
BDNF	MIG	0.028	Neg	25	10	3	3	9	0.23	0.75	0.31	0.30	3.00	0.10	0.02, 0.63
EOTAXIN	VCAM1	0.029	Pos	32	6	12	11	3	0.67	0.21	3.11	2.00	0.27	7.33	1.47, 36.67
FASL	LEPTIN	0.031	Pos	25	3	11	8	3	0.79	0.27	2.88	3.67	0.38	9.78	1.55, 61.65
LEPTIN	MCP1	0.034	Pos	23	3	12	6	2	0.80	0.25	3.20	4.00	0.33	12.00	1.56, 92.29
CD40L	IL22	0.037	Pos	25	7	8	0	10	0.53	1.00	0.53	1.13	21.00	0.05*	0.003, 1.09
EOTAXIN	VEGFD	0.038	Pos	23	1	9	8	5	0.90	0.38	2.34	9.00	0.63	14.40	1.38, 150.81
EOTAXIN	SCF	0.038	Pos	29	5	11	10	3	0.69	0.23	2.98	2.20	0.30	7.33	1.38. 38.88
LEPTIN	TNFB	0.038	Pos	29	5	11	10	3	0.69	0.23	2.98	2.20	0.30	7.33	1.38. 38.88
ENA78	MIG	0.038	Neg	24	10	2	4	8	0.17	0.67	0.25	0.20	2.00	0.10	0.01, 0.69
IL6	LEPTIN	0.040	Pos	26	5	10	9	2	0.67	0.18	3.67	2.00	0.22	9.00	1.39, 58.45
LEPTIN	RANTES	0.041	Pos	31	3	11	11	6	0.79	0.35	2.23	3.67	0.55	6.72	1.33, 33.91
IFNB	TRAIL	0.041	Pos	34	11	9	2	12	0.45	0.86	0.53	0.82	6.00	0.14	0.02, 0.78
EGF	MIG	0.041	Neg	29	12	5	3	9	0.29	0.75	0.39	0.42	3.00	0.14	0.03, 0.74
CD40L	TRAIL	0.044	Pos	26	8	5	2	11	0.38	0.85	0.45	0.63	5.50	0.11	0.02, 0.74
IFNG	IL1RA	0.045	Pos	36	9	8	3	16	0.47	0.84	0.56	0.89	5.33	0.17	0.04, 0.79
IL12P40	IL12P70	0.048	Pos	32	9	8	2	13	0.47	0.87	0.54	0.89	6.50	0.14	0.02, 0.80

* This table lists all pairs of cytokines for which the ratio of uninfected to infected samples is significantly different (Chi square p-value < 0.05) between the most common extreme tertiles [e.g., either low:low vs. high:high (positive association), or low:high vs high:low (negative association)]. The Chi square p-value is also provided, as well as the counts of uninfected (no) and infected (yes) samples in each corner. Corners are referred to as “Left” or “Right”, which generalizes to both positive and negative slopes. Pairs are ordered by p-value. The number of samples contained in the relevant extrema is shown in the “covers” column. This is the sum of the left-no, left-yes, right-no, and right-yes columns. Relative risk and odds ratios are also included. These calculations compare frequencies of incident syphilis in the left corner to those in the right corner. In some cases, the left corner has a higher frequency of incident syphilis than does the right corner, while in other cases the right corner has a higher frequency. These patterns are reflected in the relative risk and odds ratios. Odds ratio for CD40L-IL22 was computed using the Haldane–Anscombe correction to account for a zero in one cell

ISSN: 1479-5876