Mutational landscape of gastric cancer and clinical application of genomic profiling based on target next-generation sequencing

Table 1 Clinical characteristics of patients enrolled in this study according to TP53 status

Clinical characteristics	No. of patients	TP53		p value
Clinical characteristics	No. of patients	Wild type	Mutated	p value
Total	153	63 (41.18%)	90 (58.82%)
Gender
Male	103	36	67	0.025*
Female	50	27	23
Age median (range)	59 (19–80)
Stage
I	25	12	13	0.206
II	39	18	21
III	69	22	47
Lauren classification
Diffuse	50	23	27	0.163
Intestinal	47	13	34
Mixed	24	10	14
Differentiation
Poorly	62	29	33	0.21
Moderately and poorly	27	9	18
Moderately	45	14	31
Location
Cardia	24	4	20	0.011*
Gastric (fundus, body, antrum, pylorus)	122	56	66
Lymphatic metastasis
Yes	89	31	58	0.067
No	47	24	23
Drinking
Yes	21	6	15	0.228
No	127	54	73
Smoke
Yes	30	10	20	0.368
No	118	50	68
HER-2 IHC
Positive	11	2	9	0.208
Negative	110	43	67

ISSN: 1479-5876