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Table 2 Correlations between clinicopathological characteristics of patients and lymph node metastasis in the training and validation sets

From: Novel nomograms to predict lymph node metastasis and liver metastasis in patients with early colon carcinoma

Clinicopathological variables Training set Validation set
Negative Positive P value Negative Positive P value
Age 67.36 (13.31) 64.97 (13.58) 0.023 67.52 (13.36) 65.18 (13.59) 0.357
Gender
 Female 9421 1546 0.619 4704 808 0.815
 Male 9348 1565   4641 786  
Marital status
 Married 10,260 1786 0.002 5141 906 0.017
 Single 7297 1165   3593 613  
 Unknown 1212 160   611 75  
Race
 American Indian/Alaska Native 132 22   58 11 0.001
 Asian or Pacific Islander 1363 287   675 142  
 Black 2190 468   1074 224  
 White 15,084 2334   7538 1217  
Histologic grade
 Well differentiated 3790 368 < 0.001 1885 171 < 0.001
 Moderately differentiated 13,445 2189   6747 1148  
 Poorly differentiated 1292 469   620 234  
 Undifferentiated 242 85   93 41  
Histologic type
 Adenocarcinoma 16,276 2641 < 0.001 8060 1379 0.005
 Carcinoid tumor 565 79   312 30  
 Neuroendocrine carcinoma 144 50   81 16  
 Mucinous adenocarcinoma 896 179   418 92  
 Other 888 162   474 77  
T classification
 T1 10,313 1031 < 0.001 5125 548 < 0.001
 T2 8456 2080   4220 1046  
Tumor size
 <5 cm 13,949 2345 < 0.001 6984 1210 < 0.001
 ≥ 5 cm 1927 484   919 235  
 Unknown 2891 282   1442 149  
CEA
 Negative 6809 1302 < 0.001 3405 640 < 0.001
 Borderline 43 11   22 4  
 Positive 1770 500   861 254  
 Unknown 10,147 1298   5057 696  
Tumor number
 1 12,996 2218 0.125 6423 1152 0.035
 2 4315 674   2170 336  
 3 1100 162   572 80  
 > 3 358 57   180 26  
Overall survival
 Alive 16,258 2539 < 0.001 8087 1322 < 0.001
 Dead 2511 572   1258 272  
  1. Italic values: statistical differences are significant. CEA, carcinoembryonic antigen