Table 1 Demographic and clinical characteristics of colon carcinoma patients
Clinicopathological variables | SEER cohort (n = 32,819) | P value | ||
|---|---|---|---|---|
|  | Entire cohort | Training n = 21,880 | Validation n = 10,939 | |
Age | 67.08 (13.40) | 67.02 (13.38) | 67.19 (13.42) | 0.826 |
Gender | ||||
 Female | 16,479 | 10,967 | 5512 | 0.659 |
 Male | 16,340 | 10,913 | 5427 |  |
Marital status | ||||
 Married | 18,093 | 12,046 | 6047 | 0.922 |
 Single | 12,668 | 8462 | 4206 |  |
 Unknown | 2058 | 1372 | 686 |  |
Race | ||||
 American Indian/Alaska Native | 223 | 154 | 69 | 0.735 |
 Asian or Pacific Islander | 2467 | 1650 | 817 |  |
 Black | 3956 | 2658 | 1298 |  |
 White | 26,173 | 17,418 | 8755 |  |
Histological grade | ||||
 Well differentiated | 6214 | 4158 | 2056 | 0.172 |
 Moderately differentiated | 23,529 | 15,634 | 7895 |  |
 Poorly differentiated | 2615 | 1761 | 854 |  |
 Undifferentiated | 461 | 327 | 134 |  |
Histological type | ||||
 Adenocarcinoma | 28,356 | 18,917 | 9439 | 0.620 |
 Carcinoid tumor | 986 | 644 | 342 |  |
 Neuroendocrine carcinoma | 291 | 194 | 97 |  |
 Mucinous adenocarcinoma | 1585 | 1075 | 510 |  |
 Other | 1601 | 1050 | 551 |  |
TNM | ||||
 I | 27,708 | 18,482 | 9226 | 0.408 |
 II | 91 | 58 | 33 |  |
 III | 4398 | 2906 | 1492 |  |
 IV | 619 | 431 | 188 |  |
T classification | ||||
 T1 | 17,017 | 11,344 | 5673 | 0.990 |
 T2 | 15,802 | 10,536 | 5266 |  |
N classification | ||||
 N0 | 28,114 | 18,769 | 9345 | 0.277 |
 N1 | 3971 | 2623 | 1348 |  |
 N2 | 734 | 488 | 246 |  |
M classification | ||||
 M0 | 32,200 | 21,449 | 10,751 | 0.512 |
 M1 | 619 | 431 | 188 |  |
Tumor size | ||||
 < 5 cm | 24,488 | 16,294 | 8194 | 0.536 |
 ≥ 5 cm | 3565 | 2411 | 1154 |  |
 Unknown | 4766 | 3175 | 1591 |  |
Liver metastasis | ||||
 Negative | 32,364 | 21,557 | 10,807 | 0.06 |
 Positive | 455 | 323 | 132 |  |
Lung metastasis | ||||
 Negative | 32,713 | 21,801 | 10,912 | 0.09 |
 Positive | 91 | 67 | 24 |  |
 Unknown | 14 | 12 | 2 |  |
Bone metastasis | ||||
 Negative | 32,793 | 21,861 | 10,932 | 0.227 |
 Positive | 14 | 12 | 2 |  |
 Unknown | 11 | 7 | 4 |  |
Brain metastasis | ||||
 Negative | 32,798 | 21,867 | 10,931 | 0.440 |
 Positive | 5 | 4 | 1 |  |
 Unknown | 15 | 9 | 6 |  |
CEA | ||||
 Negative | 12,156 | 8111 | 4045 | 0.943 |
 Borderline | 80 | 54 | 26 |  |
 Positive | 3385 | 2270 | 1115 |  |
 Unknown | 17,198 | 11,445 | 5753 |  |
Tumor number | ||||
 1 | 22,789 | 15,214 | 7575 | 0.898 |
 2 | 7495 | 4989 | 2506 |  |
 3 | 1914 | 1262 | 652 |  |
 > 3 | 621 | 415 | 206 |  |
Overall survival | ||||
 Alive | 28,206 | 18,797 | 9409 | 0.812 |
 Dead | 4613 | 3083 | 1530 |  |