Fig. 3

SAH5-EJ1 inhibits growth and prolongs survival in PDX models of lung cancer. a, b Cell viability assays performed in A549 or EGFR T790M mutated H1975 lung adenocarcinoma cells over 3 days comparing treatment with Sapitinib (blue lines) to SAH5-EJ1 (red lines). Solid lines represent 24 h; dashed lines represent 72 h. Data shown represent mean ± percent difference of assays performed in quadruplicate. c Reduction in tumor burden in Erlotinib-resistant lung cancer PDX mouse model TM00784 with various doses of intravenous SAH5-EJ1. Control represents water as a vehicle control. *p < 0.05 (Control vs 1 µg/g); **p < 0.01 (Control vs 1 µg/g and vs 10 µg/g). d Kaplan–Meier curve of lung PDX mouse model treated with control (blue line) or either 1 or 10 µg/g SAH5-EJ1 (green line and red line, respectively). Data shown represent mean. N = 6 for all groups