Regulatory T cells and M2 macrophages present diverse prognostic value in gastric cancer patients with different clinicopathologic characteristics and chemotherapy strategies

Table 1 Clinicopathologic characteristics of the total 598 gastric cancer patients

	n	T cells									M2 macrophages			Tumor cells
		FOXP3			CD3			CD8			CD163			PD-L1
		Low (%)	High (%)	p value	Low (%)	High (%)	p-value	Low (%)	High (%)	p-value	Low (%)	High (%)	p-value	Neg (%)	Pos (%)	p-value
Gender	598			0.285			0.858			0.285			0.373			0.43
Female	180	53.3	46.7		50.6	49.4		46.7	53.3		57.8	47.2		71.7	28.3
Male	418	48.6	51.4		49.8	50.2		51.4	48.6		48.8	51.2		68.4	31.6
Age	598			0.024			0.019			0.676			0.08			0.204
≤ 60	239	55.6	44.4		43.9	56.1		49	51		54.4	45.6		66.1	33.9
> 60	359	46.2	53.8		53.8	46.2		50.7	49.3		47.1	52.9		71.6	28.4
Location	598			0.334			0.473			0.321			0.186			0.977
U	124	55.6	44.4		54.8	45.2		53.2	46.8		53.2	46.8		70.2	29.8
M	197	49.7	50.3		49.2	50.8		45.7	54.3		44.7	55.3		69	31
L	277	47.7	52.3		48.4	51.6		51.6	48.4		52.3	47.7		69.3	30.7
Pathological classification	598			< 0.001			< 0.001			< 0.001			0.004			< 0.001
Pap	14	28.6	71.4		85.7	14.3		92.9	7.1		50	50		64.3	35.7
Tub	183	49.2	50.8		54.1	45.9		53.6	46.4		51.9	48.1		51.4	48.6
Por	316	48.4	51.6		42.7	57.3		44.6	55.4		43.7	56.3		78.8	21.2
Sig & Muc	85	61.2	38.8		62.4	37.6		55.3	44.7		68.2	31.8		75.3	24.7
T stage	598			0.097			0.044			0.002			0.632			< 0.001
1	68	52.9	47.1		51.5	48.5		57.4	42.6		51.5	48.5		48.5	51.5
2	84	52.4	47.6		41.7	58.3		45.2	54.8		45.2	54.8		58.3	41.7
3	141	57.4	42.6		43.3	56.7		37.6	62.4		47.5	52.5		66	34
4	35	45.2	54.8		55.1	44.9		55	45		52.1	47.9		78.7	21.3
N stage	598			0.176			0.499			0.398			0.612			< 0.001
N0	224	46.4	53.6		48.2	51.8		47.8	52.2		51.3	48.7		53.6	46.4
N+	374	52.1	47.9		51.1	48.9		51.3	48.7		49.2	50.8		78.9	21.1
M stage	598			< 0.001			0.013			< 0.001			0.001			0.002
M0	524	55.7	44.3		48.1	51.9		46.6	53.4		52.7	47.3		67.2	32.8
M+	74	9.5	90.5		63.5	36.5		74.3	25.7		31.1	68.9		85.1	14.9
pTNM	598			< 0.001			0.082			< 0.001			0.001			< 0.001
1	108	49.1	50.9		47.2	52.8		54.7	45.3		51	49		47.3	52.7
2	150	57.3	42.7		46	54		40	60		58	42		50.7	49.3
3	266	57.5	42.5		49.6	50.4		47	53		54.5	45.5		80.5	19.5
4	74	9.5	90.5		63.5	36.5		74.3	25.7		31.1	68.9		85.1	14.9

U: upper parts; M: middle parts; L: lower parts; N0: no lymph node metastasis; N+: lymph node metastasis; Pap: papillary adenocarcinoma; Tub: tubular adenocarcinoma; Por: poor-differentiated adenocarcinoma; Sig: signet ring cell adenocarcinoma; Muc: mucinous adenocarcinoma; Neg: Negative; Pos: Postive

ISSN: 1479-5876