Fig. 4
From: Reduced eIF3d accelerates HIV disease progression by attenuating CD8+ T cell function
Knockdown of SOCS-7 restored the attenuated CD8+ T cell functions caused by a reduction in eIF3d. a CD8 + T cells were sorted from HCs. When the cells were transfected with eIF3d siRNA alone, expression of eIF3d was reduced by 66% (P = 0.043) while that of SOCS-7 was increased by 230% (P = 0.027). Co-transfection of eIF3d siRNA and SOCS-7 siRNA resulted in a 67% reduction in eIF3d (P = 0.048) and a 76% reduction in SOCS-7 expression (P = 0.038). Representative flow cytometry plots and statistical charts showing that co-transfection of eIF3d siRNA and SOCS-7 siRNA recovered the function of CD8+ T cells, including proliferation (b, c), apoptosis (d, e), and the ability to secrete IFN-γ (f, g)