Journal of Translational Medicine

Table 3 Correlation of T-cell and antibody responses in the homologous SIV-prime SIV-boost regimen

From: Virus-like vaccines against HIV/SIV synergize with a subdominant antigen T cell vaccine

a Ad-SIV + MVA-SIV	CD4+ T-cells					CD8+ T-cells					Antibodies
a Ad-SIV + MVA-SIV	Gag	Env	Rev	Vif	Vpr	Gag	Env	Rev	Vif	Vpr	AUC	Titer	Avidity
CD4+ T-cells
Gag
Env	0.086
Rev	0.085	0.834
Vif	0.694	0.250	0.792
Vpr	0.262	0.731	0.342	0.444
CD8+ T-cells
Gag	0.678	1.018	0.151	0.500	0.363
Env	0.437	0.410	0.611	0.889	0.082	0.017
Rev	0.516	0.131	0.960	0.583	0.187	0.226	0.226
Vif	0.476	0.901	0.181	1.000	0.782	0.615	0.460	0.940
Vpr	0.667	1.111	0.889	0.222	0.889	0.667	0.444	1.000	0.333
Antibodies
AUC	0.097	0.776	0.228	0.944	0.853	0.644	0.948	0.583	0.226	0.444
Titer	0.263	0.630	0.337	0.889	0.673	0.616	0.913	0.230	0.480	0.667	0.001
Avidity	0.083	1.000	0.139	1.583	0.056	0.583	0.778	1.417	1.417	1.778	1.000	0.750

b Ad-SIV + Ad-Ii-SIVCErvv + MVA-SIV	CD4+ T-cells					CD8+ T-cells					Antibodies
b Ad-SIV + Ad-Ii-SIVCErvv + MVA-SIV	Gag	Env	Rev	Vif	Vpr	Gag	Env	Rev	Vif	Vpr	AUC	Titer	Avidity
CD4+ T-cells
Gag
Env	0.046
Rev	0.629	0.015
Vif	0.182	0.223	0.079
Vpr	0.014	0.002	0.074	0.111
CD8+ T-cells
Gag	0.461	0.496	0.463	0.459	0.862
Env	0.296	0.106	0.256	0.866	0.305	0.081
Rev	0.503	0.777	0.430	0.150	0.307	0.125	0.828
Vif	0.665	0.909	0.748	0.955	0.456	0.911	0.306	0.763
Vpr	0.116	0.480	0.896	1.002	0.082	0.220	0.845	0.144	0.199
Antibodies
AUC	0.075	0.164	0.515	0.477	0.221	0.843	0.230	0.422	0.389	0.853
Titer	0.040	0.157	0.558	0.272	0.085	0.738	0.629	0.725	0.410	0.512	0.004
Avidity	0.053	0.112	0.458	0.346	0.127	0.804	0.601	0.495	0.798	0.798	0.002	0.002

p-values of Spearman correlation in MVA-SIV-boosted groups a without Ad-Ii-SIVCErvv and b with Ad-Ii-SIVCErvv. p-values that remained significant after adjustment with the Holm–Sidak-method are marked in italic

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ISSN: 1479-5876

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