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Table 3 Correlation of T-cell and antibody responses in the homologous SIV-prime SIV-boost regimen

From: Virus-like vaccines against HIV/SIV synergize with a subdominant antigen T cell vaccine

a
Ad-SIV
+ MVA-SIV
CD4+ T-cells CD8+ T-cells Antibodies
Gag Env Rev Vif Vpr Gag Env Rev Vif Vpr AUC Titer Avidity
CD4+ T-cells
Gag              
Env 0.086             
Rev 0.085 0.834            
Vif 0.694 0.250 0.792           
Vpr 0.262 0.731 0.342 0.444          
CD8+ T-cells
Gag 0.678 1.018 0.151 0.500 0.363         
Env 0.437 0.410 0.611 0.889 0.082 0.017        
Rev 0.516 0.131 0.960 0.583 0.187 0.226 0.226       
Vif 0.476 0.901 0.181 1.000 0.782 0.615 0.460 0.940      
Vpr 0.667 1.111 0.889 0.222 0.889 0.667 0.444 1.000 0.333     
Antibodies
AUC 0.097 0.776 0.228 0.944 0.853 0.644 0.948 0.583 0.226 0.444    
Titer 0.263 0.630 0.337 0.889 0.673 0.616 0.913 0.230 0.480 0.667 0.001   
Avidity 0.083 1.000 0.139 1.583 0.056 0.583 0.778 1.417 1.417 1.778 1.000 0.750  
b
Ad-SIV +
Ad-Ii-SIVCErvv
+ MVA-SIV
CD4+ T-cells CD8+ T-cells Antibodies
Gag Env Rev Vif Vpr Gag Env Rev Vif Vpr AUC Titer Avidity
CD4+ T-cells
Gag              
Env 0.046             
Rev 0.629 0.015            
Vif 0.182 0.223 0.079           
Vpr 0.014 0.002 0.074 0.111          
CD8+ T-cells
Gag 0.461 0.496 0.463 0.459 0.862         
Env 0.296 0.106 0.256 0.866 0.305 0.081        
Rev 0.503 0.777 0.430 0.150 0.307 0.125 0.828       
Vif 0.665 0.909 0.748 0.955 0.456 0.911 0.306 0.763      
Vpr 0.116 0.480 0.896 1.002 0.082 0.220 0.845 0.144 0.199     
Antibodies
AUC 0.075 0.164 0.515 0.477 0.221 0.843 0.230 0.422 0.389 0.853    
Titer 0.040 0.157 0.558 0.272 0.085 0.738 0.629 0.725 0.410 0.512 0.004   
Avidity 0.053 0.112 0.458 0.346 0.127 0.804 0.601 0.495 0.798 0.798 0.002 0.002  
  1. p-values of Spearman correlation in MVA-SIV-boosted groups a without Ad-Ii-SIVCErvv and b with Ad-Ii-SIVCErvv. p-values that remained significant after adjustment with the Holm–Sidak-method are marked in italic