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Table 2 Correlation of T-cell and antibody responses in the heterologous HIV-prime SIV-boost regimen

From: Virus-like vaccines against HIV/SIV synergize with a subdominant antigen T cell vaccine

a
Ad-HIVB
+MVA-SIV
CD4+ T-cells CD8+ T-cells Antibodies
HIV
conB Gag
SIV
mac Gag
SIV CE SIV
agm Gag
HIV
conB Env
SIV
mac Env
HIV
conB Gag
SIV
mac Gag
SIV CE SIV
agm Gag
HIV
conB Env
SIV
mac Env
anti-HIV B
Env
anti-SIV
mac Env
anti-HIV C
Env
CD4+ T-cells
HIVconB Gag                
SIVmac Gag 0.479               
SIV CE 0.333 0.292              
SIVagm Gag 0.022 0.533 0.689             
HIVconB Env 0.019 0.673 0.275 0.044            
SIVmac Env 0.096 0.977 0.400 0.044 0.098           
CD8+ T-cells
HIVconB Gag 0.233 0.453 0.306 0.800 0.648 0.513          
SIVmac Gag 0.043 0.984 0.785 0.400 0.211 0.072 0.023         
SIV CE 0.600 0.900 0.100 1.000 0.200 0.800 0.600 0.800        
SIVagm Gag                
HIVconB Env 0.007 1.000 0.253 0.044 0.012 0.017 0.072 0.002 0.200       
SIVmac Env 0.931 0.333 0.067 0.611 1.000 1.000 0.214 0.500 0.200   0.722     
Antibodies
anti-HIV B Env 0.330 0.274 0.025 0.956 0.442 0.427 0.013 0.159 0.200   0.187 0.008    
anti-SIVmac Env 0.973 0.794 0.531 0.867 0.556 0.233 0.407 0.246 0.600   0.335 0.039 0.096   
anti-HIV C Env 0.707 0.962 0.264 0.911 0.383 0.387 0.096 0.199 0.400   0.230 0.031 0.015 0.001  
b
Ad-HIVB + Ad-Ii-SIVCErvv
+MVA-SIV
CD4+ T-cells CD8+ T-cells Antibodies
HIV
conB Gag
SIV
mac Gag
SIV CE SIV
agm Gag
HIV
conB Env
SIV
mac Env
HIV
conB Gag
SIV
mac Gag
SIV CE SIV
agm Gag
HIV
conB Env
SIV
mac
Env
anti-HIV B
Env
anti-SIV
mac Env
anti-HIV C
Env
CD4+ T-cells
HIVconB Gag                
SIVmac Gag 0.110               
SIV CE 0.300 0.006              
SIVagm Gag 0.064 2.6E−04 0.010             
HIVconB Env 0.645 0.010 0.024 0.042            
SIVmac Env 0.042 0.599 0.475 0.639 1.000           
CD8+ T-cells
HIVconB Gag 5.5E−07 0.110 0.300 0.064 0.645 0.042          
SIVmac Gag 0.110 6.6E−06 0.006 2.6E−04 0.010 0.599 0.110         
SIV CE 0.300 0.006 6.6E−06 0.010 0.024 0.475 0.300 0.006        
SIVagm Gag 0.064 2.6E−04 0.010 3.3E−05 0.042 0.639 0.064 2.6E−04 0.010       
HIVconB Env 0.645 0.010 0.024 0.042 5.5E−07 1.000 0.645 0.010 0.024 0.042      
SIVmac Env 0.042 0.599 0.475 0.639 1.000 0.001 0.042 0.599 0.475 0.639 1.000     
Antibodies
anti-HIV B Env 0.075 0.299 0.122 0.215 0.462 0.008 0.075 0.299 0.122 0.215 0.462 0.008    
anti-SIVmac Env 0.168 0.205 0.552 0.316 0.162 0.156 0.168 0.205 0.552 0.316 0.162 0.156 0.096   
anti-HIV C Env 0.125 0.528 0.375 0.394 0.399 0.039 0.125 0.528 0.375 0.394 0.399 0.039 0.002 0.031  
  1. p-values of Spearman correlation in MVA-SIV-boosted groups a without Ad-Ii-SIVCErvv and b with Ad-Ii-SIVCErvv. p-values that remained significant after adjustment with the Holm–Sidak-method are marked in italic