Virus-like vaccines against HIV/SIV synergize with a subdominant antigen T cell vaccine

Table 2 Correlation of T-cell and antibody responses in the heterologous HIV-prime SIV-boost regimen

b Ad-HIVB + Ad-Ii-SIVCErvv +MVA-SIV	CD4+ T-cells						CD8+ T-cells						Antibodies
b Ad-HIVB + Ad-Ii-SIVCErvv +MVA-SIV	HIV conB Gag	SIV mac Gag	SIV CE	SIV agm Gag	HIV conB Env	SIV mac Env	HIV conB Gag	SIV mac Gag	SIV CE	SIV agm Gag	HIV conB Env	SIV mac Env	anti-HIV B Env	anti-SIV mac Env	anti-HIV C Env
CD4+ T-cells
HIVconB Gag
SIVmac Gag	0.110
SIV CE	0.300	0.006
SIVagm Gag	0.064	2.6E−04	0.010
HIVconB Env	0.645	0.010	0.024	0.042
SIVmac Env	0.042	0.599	0.475	0.639	1.000
CD8+ T-cells
HIVconB Gag	5.5E−07	0.110	0.300	0.064	0.645	0.042
SIVmac Gag	0.110	6.6E−06	0.006	2.6E−04	0.010	0.599	0.110
SIV CE	0.300	0.006	6.6E−06	0.010	0.024	0.475	0.300	0.006
SIVagm Gag	0.064	2.6E−04	0.010	3.3E−05	0.042	0.639	0.064	2.6E−04	0.010
HIVconB Env	0.645	0.010	0.024	0.042	5.5E−07	1.000	0.645	0.010	0.024	0.042
SIVmac Env	0.042	0.599	0.475	0.639	1.000	0.001	0.042	0.599	0.475	0.639	1.000
Antibodies
anti-HIV B Env	0.075	0.299	0.122	0.215	0.462	0.008	0.075	0.299	0.122	0.215	0.462	0.008
anti-SIVmac Env	0.168	0.205	0.552	0.316	0.162	0.156	0.168	0.205	0.552	0.316	0.162	0.156	0.096
anti-HIV C Env	0.125	0.528	0.375	0.394	0.399	0.039	0.125	0.528	0.375	0.394	0.399	0.039	0.002	0.031

p-values of Spearman correlation in MVA-SIV-boosted groups a without Ad-Ii-SIVCErvv and b with Ad-Ii-SIVCErvv. p-values that remained significant after adjustment with the Holm–Sidak-method are marked in italic

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