Fig. 2
From: Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia
a AML cell lines THP-1, HL-60 and Kasumi-1 were treated with increasing concentrations of triptolide and cell viability was evaluated using ATP based luciferase assay. Treatment with triptolide decreased cell proliferation in all cell lines at low nano-molar doses. b This decrease in viability corresponded to an increase in apoptotic cell death as measured by the activity of caspase 3. c In patient blast samples, triptolide caused cell death with an IC-50 in the range of 4 nm to 17 nM, n = 3, *p < 0.05 when compared to untreated cells, data shows mean ± SD