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Table 2 Cox-model-measured hazard ratios and 95% confidence intervals of chronic fatigue syndrome associated with psoriasis and covariates

From: Increased risk of chronic fatigue syndrome following psoriasis: a nationwide population-based cohort study

Variable

Event no.

Person-years

IR

HR (95% CI)

Univariate

Multivariatea

Psoriasis

 No

126

55,446

2.27

1.00

1.00

 Yes

50

13,958

3.58

1.58 (1.14–2.19)**

1.48 (1.07–2.06)*

Sex

 Women

91

32,509

2.80

1.00

1.00

 Men

85

36,895

2.30

0.82 (0.61–1.11)

0.86 (0.64–1.17)

Age, years

 20–39

62

31,599

1.96

1.00

1.00

 40–59

60

23,974

2.50

1.28 (0.90–1.82)

1.17 (0.81–1.68)

 ≥ 60

54

13,832

3.90

1.99 (1.38–2.87)***

1.64 (1.10–2.45)*

Comorbidity

 Diabetes

  No

158

63,598

2.48

1.00

1.00

  Yes

18

5806

3.10

1.25 (0.77–2.03)

0.83 (0.49–1.38)

 Depression

  No

158

66,645

2.37

1.00

1.00

  Yes

18

2760

6.52

2.75 (1.69–4.48)***

1.51 (0.89–2.57)

 Anxiety

  No

153

65,385

2.34

1.00

1.00

  Yes

23

4020

5.72

2.44 (1.58–3.79)***

1.30 (0.80–2.11)

 Sleep disorder

  No

115

58,403

1.97

1.00

1.00

  Yes

61

11,002

5.54

2.81 (2.06–3.84)***

2.17 (1.53–3.08)***

 Renal disease

  No

161

66,170

2.43

1.00

1.00

  Yes

15

3234

4.64

1.91 (1.13–3.24)*

1.26 (0.73–2.20)

  1. IR incidence density rate per 1000 person-years, HR hazard ratio, CI confidence interval
  2. * P < 0.05, ** P < 0.01, *** P < 0.001
  3. aAdjusted for psoriasis, sex, age (categorical), diabetes, depression, anxiety, sleep disorder, and renal disease