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Table 1 Correlations between IHC markers and tumor characteristics and survival

From: Effect of chemotherapy on cancer stem cells and tumor-associated macrophages in a prospective study of preoperative chemotherapy in soft tissue sarcoma

  Baseline SUVmax Post-chemo SUVmax % change in SUVmax Synovial vs othera % viable cells post-chemo Change in tumor size Survival
Baseline IHC
 ALDH1% positive, n = 30 No No No No No No No
 ALDH intensity, n = 30 No No No No No No Higher in alive, p = 0.100
 CD44% positive, n = 30 No R = 0.46, p = 0.014 No Lower in SS p = 0.005 No No No
 CD44 intensity, n = 30 R = 0.36, p = 0.048 R = 0.36, p = 0.057 No Lower in SS p = 0.073 No No No
 CD68% positive, n = 28 R = 0.38, p = 0.044 No No Lower in SS p = 0.058 R = − 0.37, p = 0.051 No No
 CD31% positive, n = 27 No R = − 0.39, p = 0.051 R = 0.45, p = 0.022 No R = − 0.30, p = 0.126 R = − 0.55, p = 0.004 No
Post-chemotherapy IHC
 ALDH1% positive, n = 14 No No No No R = 0.32, p = 0.260 R = 0.41, p = 0.166 No
 ALDH intensity, n = 14 No No No No R = 0.39, p = 0.168 R = 0.54, p = 0.055 No
 CD44% positive, n = 24 R = 0.34, p = 0.101 R = 0.44, p = 0.043 No Lower in SS, p = 0.010 No R = − 0.39, p = 0.073 No
 CD44 intensity, n = 24 R = 0.50, p = 0.013 No No No No R = − 0.42, p = 0.049 No
 CD68% positive, n = 26 R = 0.36, p = 0.068 R = 0.34, p = 0.105 No Lower in SS, p = 0.004 R = − 0.44, p = 0.023 No No
 CD31% positive, n = 22 No R = − 0.30, p = 0.197 R = 0.38, p = 0.096 No No R = 0.46, p = 0.036 No
Change for post- minus pre-chemotherapy IHC
 ALDH1% positive, n = 14 No No No No No R = 0.38, p = 0.199 No
 ALDH1 intensity, n = 14 No No No No R = 0.31, p = 0.285 R = 0.48, p = 0.098 No
 CD44% positive, n = 24 No No No No No No No
 CD44 intensity, n = 24 No R = − 0.40, p = 0.066 No Higher in SS, p = 0.050 No No No
 CD68% positive, n = 24 No No No Lower in SS, p = 0.046 No No No
 CD31% positive, n = 20 No No R = − 0.35, p = 0.155 No No No No
  1. A “no” value indicates no association as defined by an R value > − 0.03 and < 0.3; SS
  2. aSynovial sarcoma