Table 1 Correlations between IHC markers and tumor characteristics and survival
Baseline SUVmax | Post-chemo SUVmax | % change in SUVmax | Synovial vs othera | % viable cells post-chemo | Change in tumor size | Survival | |
|---|---|---|---|---|---|---|---|
Baseline IHC | |||||||
ALDH1% positive, n = 30 | No | No | No | No | No | No | No |
ALDH intensity, n = 30 | No | No | No | No | No | No | Higher in alive, p = 0.100 |
CD44% positive, n = 30 | No | R = 0.46, p = 0.014 | No | Lower in SS p = 0.005 | No | No | No |
CD44 intensity, n = 30 | R = 0.36, p = 0.048 | R = 0.36, p = 0.057 | No | Lower in SS p = 0.073 | No | No | No |
CD68% positive, n = 28 | R = 0.38, p = 0.044 | No | No | Lower in SS p = 0.058 | R = − 0.37, p = 0.051 | No | No |
CD31% positive, n = 27 | No | R = − 0.39, p = 0.051 | R = 0.45, p = 0.022 | No | R = − 0.30, p = 0.126 | R = − 0.55, p = 0.004 | No |
Post-chemotherapy IHC | |||||||
ALDH1% positive, n = 14 | No | No | No | No | R = 0.32, p = 0.260 | R = 0.41, p = 0.166 | No |
ALDH intensity, n = 14 | No | No | No | No | R = 0.39, p = 0.168 | R = 0.54, p = 0.055 | No |
CD44% positive, n = 24 | R = 0.34, p = 0.101 | R = 0.44, p = 0.043 | No | Lower in SS, p = 0.010 | No | R = − 0.39, p = 0.073 | No |
CD44 intensity, n = 24 | R = 0.50, p = 0.013 | No | No | No | No | R = − 0.42, p = 0.049 | No |
CD68% positive, n = 26 | R = 0.36, p = 0.068 | R = 0.34, p = 0.105 | No | Lower in SS, p = 0.004 | R = − 0.44, p = 0.023 | No | No |
CD31% positive, n = 22 | No | R = − 0.30, p = 0.197 | R = 0.38, p = 0.096 | No | No | R = 0.46, p = 0.036 | No |
Change for post- minus pre-chemotherapy IHC | |||||||
ALDH1% positive, n = 14 | No | No | No | No | No | R = 0.38, p = 0.199 | No |
ALDH1 intensity, n = 14 | No | No | No | No | R = 0.31, p = 0.285 | R = 0.48, p = 0.098 | No |
CD44% positive, n = 24 | No | No | No | No | No | No | No |
CD44 intensity, n = 24 | No | R = − 0.40, p = 0.066 | No | Higher in SS, p = 0.050 | No | No | No |
CD68% positive, n = 24 | No | No | No | Lower in SS, p = 0.046 | No | No | No |
CD31% positive, n = 20 | No | No | R = − 0.35, p = 0.155 | No | No | No | No |