Fig. 6

a Volcano plot of the miRNAs between normal brain and glioma samples. Red dots indicate upregulated genes, and green dots indicate downregulated genes. Black dots show the genes with expression of |log₂FC| < 1. The Y axis represents an FDR, and the X axis represents the value of log₂FC. b Hierarchical clustering based on the expression profiles of significantly differentially expressed miRNAs. c miRNA–mRNA regulatory interaction networks. The results show that hsa-let-7b-5p targets PLK1, CCNA2, CCNB2, and AURKA directly