Table 1 Serum and urine parameters
Parameters | Sham + vehicle | Sham + canagliflozin | IRI + vehicle | IRI + canagliflozin |
|---|---|---|---|---|
Serum glucose (mg/dL) | 215 ± 15 | 193 ± 10 | 205 ± 13 | 226 ± 17 |
Urine glucose (mmol/L) | 0.54 ± 0.06 | 0.49 ± 0.06 | 0.44 ± 0.06 | 0.52 ± 0.04 |
Serum creatine kinase (IU/L) | 1778 ± 247 | 1806 ± 346 | 3445 ± 436* | 3089 ± 477 |
Serum lactate dehydrogenase (IU/L) | 961 ± 81 | 789 ± 41 | 3279 ± 259* | 2716 ± 242* |
Serum aspartate transaminase (IU/L) | 217 ± 23 | 191 ± 10 | 899 ± 119* | 745 ± 91* |
Serum alanine transaminase (IU/L) | 63 ± 4 | 57 ± 5 | 131 ± 11* | 114 ± 12* |
Alkaline phosphatase (IU/L) | 268 ± 10 | 277 ± 13 | 273 ± 13 | 304 ± 15 |
Cholesterol (mg/dL) | 79 ± 4 | 82 ± 4 | 78 ± 4 | 77 ± 2 |
Creatinine (mg/dL) | 0.47 ± 0.05 | 0.42 ± 0.02 | 0.58 ± 0.08 | 0.55 ± 0.05 |
Urinary urea nitrogen (g/dL) | 27 ± 5 | 26 ± 3 | 21 ± 4 | 20 ± 2 |
Urinary creatinine (mg/dL) | 103 ± 9 | 115 ± 11 | 116 ± 12 | 99 ± 8 |
Urinary albumin (mg/L) | 16 ± 3 | 13 ± 6 | 16 ± 4 | 15 ± 3 |