Fig. 5
Effect of canagliflozin on vasorelaxation. a End-systolic blood pressure and arterial elastance of vehicle-treated (sham + vehicle, n = 7) and canagliflozin-treated (sham + canagliflozin, n = 7) healthy (sham-operated) rats from the second part of the in vivo study. b Effect of canagliflozin on endothelium-dependent vasorelaxation in healthy aortic rings in vitro (n = 10 aortic rings in each group). c Effect of canagliflozin on endothelium-independent vasorelaxation in healthy aortic rings in vitro (n = 10 aortic rings in each group). Student t-test P values are reported with ticked lines between two groups or as: *P < 0.05. ACh acetylcholine, cana canagliflozin, DMSO dimethyl sulfoxide, pD2 − logEC50, Rmax maximal vasorelaxation, SNP sodium nitroprusside