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Table 2 Cox proportional hazards regression analyses on the relationship between hypoxia and ClockLoss or ClockGain on overall survival

From: Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

  Hazard ratio (95% CI) P-value
Glioma (ClockLoss)
 Low ClockLoss and high hypoxia score vs. low ClockLoss and low hypoxia score 7.218 (4.234–12.304) <0.0001
 High ClockLoss and high hypoxia score vs. low ClockLoss and low hypoxia score 3.138 (1.733–5.683) 0.00016
 High ClockLoss and low hypoxia score vs. low ClockLoss and low hypoxia score 1.114 (0.617–2.014) 0.72
Pan-kidney (ClockLoss)
 Low ClockLoss and high hypoxia score vs. low ClockLoss and low hypoxia score 2.512 (1.732–3.643) <0.0001
 High ClockLoss and high hypoxia score vs. low ClockLoss and low hypoxia score 1.580 (1.094–2.282) 0.0148
 High ClockLoss and low hypoxia score vs. low ClockLoss and low hypoxia score 0.695 (0.423–1.122) 0.14
Clear cell renal cell (ClockLoss)
 Low ClockLoss and high hypoxia score vs. low ClockLoss and low hypoxia score 1.893 (1.207–2.969) 0.0054
 High ClockLoss and high hypoxia score vs. low ClockLoss and low hypoxia score 1.285 (0.761–2.170) 0.35
 High ClockLoss and low hypoxia score vs. low ClockLoss and low hypoxia score 0.796 (0.479–1.324) 0.38
Glioma (ClockGain)
 High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 9.210 (6.182–13.721) <0.0001
 High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score 1.550 (0.917–2.622) 0.11
 Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 3.317 (2.105–5.228) <0.0001
Astrocytoma (ClockGain)
 High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 5.684 (2.770–11.662) <0.0001
 High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score 1.451 (0.527–3.998) 0.47
 Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 2.378 (0.985–5.736) 0.054
Oligodendroglioma (ClockGain)
 High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 4.085 (1.656–10.068) 0.0022
 High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score 1.218 (0.439–3.374) 0.71
 Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 1.541 (0.581–4.091) 0.38
Pan-kidney (ClockGain)
 High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 3.079 (2.040–4.646) <0.0001
 High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score 1.742 (1.089–2.785) 0.021
 Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 2.823 (1.850–4.307) <0.0001
Clear cell renal cell (ClockGain)
 High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 1.877 (1.222–2.884) 0.0041
 High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score 1.189 (0.742–1.908) 0.47
 Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 1.630 (1.043–2.546) 0.032
Lung (ClockGain)
 High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 2.037 (1.327–3.129) 0.0012
 High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score 1.332 (0.755–2.351) 0.33
 Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 1.995 (1.221–3.258) 0.0058
Pancreas (ClockGain)
 High ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 1.976 (1.163–3.357) 0.012
 High ClockGain and low hypoxia score vs. low ClockGain and low hypoxia score 0.852 (0.344–2.110) 0.73
 Low ClockGain and high hypoxia score vs. low ClockGain and low hypoxia score 0.893 (0.397–2.009) 0.79
  1. Significant P values are marked in italics
  2. CI confidence interval