Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

Chang, Wai Hoong; Lai, Alvina G.

doi:10.1186/s12967-019-1880-9

Table 2 Cox proportional hazards regression analyses on the relationship between hypoxia and Clock^Loss or Clock^Gain on overall survival

From: Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

	Hazard ratio (95% CI)	P-value
Glioma (Clock^Loss)
Low Clock^Loss and high hypoxia score vs. low Clock^Loss and low hypoxia score	7.218 (4.234–12.304)	< 0.0001
High Clock^Loss and high hypoxia score vs. low Clock^Loss and low hypoxia score	3.138 (1.733–5.683)	0.00016
High Clock^Loss and low hypoxia score vs. low Clock^Loss and low hypoxia score	1.114 (0.617–2.014)	0.72
Pan-kidney (Clock^Loss)
Low Clock^Loss and high hypoxia score vs. low Clock^Loss and low hypoxia score	2.512 (1.732–3.643)	< 0.0001
High Clock^Loss and high hypoxia score vs. low Clock^Loss and low hypoxia score	1.580 (1.094–2.282)	0.0148
High Clock^Loss and low hypoxia score vs. low Clock^Loss and low hypoxia score	0.695 (0.423–1.122)	0.14
Clear cell renal cell (Clock^Loss)
Low Clock^Loss and high hypoxia score vs. low Clock^Loss and low hypoxia score	1.893 (1.207–2.969)	0.0054
High Clock^Loss and high hypoxia score vs. low Clock^Loss and low hypoxia score	1.285 (0.761–2.170)	0.35
High Clock^Loss and low hypoxia score vs. low Clock^Loss and low hypoxia score	0.796 (0.479–1.324)	0.38
Glioma (Clock^Gain)
High Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	9.210 (6.182–13.721)	< 0.0001
High Clock^Gain and low hypoxia score vs. low Clock^Gain and low hypoxia score	1.550 (0.917–2.622)	0.11
Low Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	3.317 (2.105–5.228)	< 0.0001
Astrocytoma (Clock^Gain)
High Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	5.684 (2.770–11.662)	< 0.0001
High Clock^Gain and low hypoxia score vs. low Clock^Gain and low hypoxia score	1.451 (0.527–3.998)	0.47
Low Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	2.378 (0.985–5.736)	0.054
Oligodendroglioma (Clock^Gain)
High Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	4.085 (1.656–10.068)	0.0022
High Clock^Gain and low hypoxia score vs. low Clock^Gain and low hypoxia score	1.218 (0.439–3.374)	0.71
Low Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	1.541 (0.581–4.091)	0.38
Pan-kidney (Clock^Gain)
High Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	3.079 (2.040–4.646)	< 0.0001
High Clock^Gain and low hypoxia score vs. low Clock^Gain and low hypoxia score	1.742 (1.089–2.785)	0.021
Low Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	2.823 (1.850–4.307)	< 0.0001
Clear cell renal cell (Clock^Gain)
High Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	1.877 (1.222–2.884)	0.0041
High Clock^Gain and low hypoxia score vs. low Clock^Gain and low hypoxia score	1.189 (0.742–1.908)	0.47
Low Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	1.630 (1.043–2.546)	0.032
Lung (Clock^Gain)
High Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	2.037 (1.327–3.129)	0.0012
High Clock^Gain and low hypoxia score vs. low Clock^Gain and low hypoxia score	1.332 (0.755–2.351)	0.33
Low Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	1.995 (1.221–3.258)	0.0058
Pancreas (Clock^Gain)
High Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	1.976 (1.163–3.357)	0.012
High Clock^Gain and low hypoxia score vs. low Clock^Gain and low hypoxia score	0.852 (0.344–2.110)	0.73
Low Clock^Gain and high hypoxia score vs. low Clock^Gain and low hypoxia score	0.893 (0.397–2.009)	0.79

Significant P values are marked in italics
CI confidence interval

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