Fig. 2

Prognostic significance of Clock^Loss and Clock^Gain. Kaplan–Meier plots are generated using a Clock^Loss and b Clock^Gain. Patients are quartile stratified based on their clock gene scores. P values are obtained from log-rank tests. c Ordination plots of multidimensional scaling analyses using Clock^Loss genes reveal significant differences between tumour and non-tumour samples. P values are obtained from PERMANOVA tests. d Expression distribution of Clock^Gain scores in tumour and non-tumour samples with statistical analyses performed using Mann–Whitney–Wilcoxon tests. P values are represented by ****< 0.00001. ns non-significant