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Table 2 Patients presenting with concomitant and multiple mutations in the KRAS, NRAS, BRAF and/or PIK3CA genes

From: Clinico-pathological associations and concomitant mutations of the RAS/RAF pathway in metastatic colorectal cancer

Patient ID

Gene

aa substitution

AF

K22-13

KRAS

G12S

0.11

KRAS

G12V

0.1

PIK3CA

D725N

0.08

PIK3CA

H1047Y

0.16

K26-13

KRAS

G12D

0.39

KRAS

T58I

0.08

BRAF

S467L

0.12

K60-14

KRAS

G12C

0.1

KRAS

G13C

0.11

KRAS

G12V

0.12

K13-14

KRAS

G12D

0.31

KRAS

V9F

0.09

BRAF

R603L

0.16

K41-14

KRAS

A59E

0.27

KRAS

G12S

0.08

NRAS

G12V

0.07

K65-13

KRAS

A146V

0.44

BRAF

G466V

0.33

K168-13

KRAS

G12V

0.47

KRAS

G15S

0.07

K35-13

KRAS

G12C

0.06

KRAS

G13D

0.54

K197-13

KRAS

G13V

0.46

NRAS

G13S

0.06

K10-14

KRAS

G12D

0.06

BRAF

G466V

0.11

K176-13

BRAF

S467L

0.09

BRAF

V600M

0.09

  1. aa, amino acid; AF, allelic frequency