Skip to main content

Table 1 Baseline characteristics stratified by AKI status

From: Fibroblast growth factor 23, endothelium biomarkers and acute kidney injury in critically-ill patients

Characteristic No-severe AKI (n = 183) Severe AKI (n = 82) p
Demographics
Age, mean ± SD 51.2 ± 17.2 51.7 ± 19.1 0.82
Male, n (%) 94 (51.4) 40 (48.8) 0.70
BMI greater than 30 kg/m2 34 (18.6) 22 (26.8) 0.14
Diabetes mellitus 31 (16.9) 19 (23.1) 0.23
Charlson comorbidity index, median (IQR) 1 (1–2) 1 (1–3) 0.52
Baseline kidney function
Baseline sCr level, median (IQR) 0.6 (0.4–0.7) 0.9 (0.5–1.7) < 0.001
eGFR, median (IQR) 109 (92–124) 85 (49–115) < 0.001
Nephrotoxic drugs 28 (15.3) 27 (32.9) 0.002
Disease severity
Sepsis, n (%) 48 (26.2) 34 (41.5) 0.015
Surgical ICU 77 (42.1) 11 (13.4) < 0.001
Mechanical Ventilation, n (%) 68 (37.2) 52 (63.4) < 0.001
Vasoactive drugs (n, %) 49 (26.8) 50 (61.0) < 0.001
APACHE II score, median (IQR) 15 (11–20) 21 (17–27) < 0.001
Plasma FGF23, median (IQR) 135.3 (10.4–544.3) 927.1 (197.6–1232.6) < 0.001
  1. AKI acute kidney injury, eGFR estimated glomerular filtration rate, sCr serum creatinine
  2. Age: years; sCr: mg/dL; eGFR: mL/min/1.73 m2; FGF23: RU/mL