Table 1 Baseline characteristics stratified by AKI status
Characteristic | No-severe AKI (n = 183) | Severe AKI (n = 82) | p |
|---|---|---|---|
Demographics | |||
Age, mean ± SD | 51.2 ± 17.2 | 51.7 ± 19.1 | 0.82 |
Male, n (%) | 94 (51.4) | 40 (48.8) | 0.70 |
BMI greater than 30 kg/m2 | 34 (18.6) | 22 (26.8) | 0.14 |
Diabetes mellitus | 31 (16.9) | 19 (23.1) | 0.23 |
Charlson comorbidity index, median (IQR) | 1 (1–2) | 1 (1–3) | 0.52 |
Baseline kidney function | |||
Baseline sCr level, median (IQR) | 0.6 (0.4–0.7) | 0.9 (0.5–1.7) | < 0.001 |
eGFR, median (IQR) | 109 (92–124) | 85 (49–115) | < 0.001 |
Nephrotoxic drugs | 28 (15.3) | 27 (32.9) | 0.002 |
Disease severity | |||
Sepsis, n (%) | 48 (26.2) | 34 (41.5) | 0.015 |
Surgical ICU | 77 (42.1) | 11 (13.4) | < 0.001 |
Mechanical Ventilation, n (%) | 68 (37.2) | 52 (63.4) | < 0.001 |
Vasoactive drugs (n, %) | 49 (26.8) | 50 (61.0) | < 0.001 |
APACHE II score, median (IQR) | 15 (11–20) | 21 (17–27) | < 0.001 |
Plasma FGF23, median (IQR) | 135.3 (10.4–544.3) | 927.1 (197.6–1232.6) | < 0.001 |